摘要
目的:研制吲达帕胺胶囊并对其溶出度进行考察。方法:溶出介质选用乙醇-水(5:895)900mL,用紫外分光光度法测定其溶出度,测定波长为240nm。测定吲达帕胺胶囊在不同转速及不同时间的累积溶出量。结果:转速为 75r·min-1,取样时间为4.5min,吲达帕胺胶囊的溶出度均大于标示量的70％。结论:所研制的吲达帕胺胶囊溶出度符合要求。
Objective:To prepare indapamide capsules and evaluate its dissolution. Method: Alcohol-distilled water (5:895) 900mL was used as dissolution medium, the content of indapamide capsules was determined by UV,detection wavelength was 240nm.The percents of cumulative dissolution at different rotating speed and sampling time were determined. Results: At the rotating speed of 75 r· min-1 ,the dissolved amount of all the indapamide capsules during 45minutes were more than 70% of labelled amount. Conclusion: The dissolution of indapamide capsules are coincidence with requirement.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2004年第1期44-46,共3页
Chinese Journal of New Drugs
