摘要
目的：建立测定吲达帕胺人体内血药浓度的方法.方法：健康男性志愿者10名空腹服用吲达帕胺胶囊7.5mg,采用高效液相色谱法测定其经-时血药浓度并计算其药动学参数.结果：药动学参数为Cmax（0.212±0.167）mg/L、tmax（2.14±0.59）h、t1/2（19.69±0.75）h、AUC0～72（3.636±0.503）（mg·L）/h、AUC0～∝（3.937±0.518）（mg·L）/h.结论：建立的血药浓度测定方法可用于吲达帕胺的临床用药分析和药动学研究.
OBJECTIVE： To establish a method for the determination of serum indapamide concentration. METHOD： 10 healthy male volunteers were assigned to receive 7.5mg indapamide capsule on empty stomach with time- concentration determined by HPLC, and the pharmacokinetics parameters were accounted. RESULTS： C was （0.212±0,167） mg/L, tmax was （2.14±0.59） h, t1/2 was （19.69±0.75） h,AUC0-72was （3.636±0.503） （mg.L）/h and AUCo-x was （3.937±0.518） （mg.L）/ h. CONCLUSION： The established method can be used for the clinical analysis on the use of indapamide and its pharmacokinetics study.
出处
《中国药房》
CAS
CSCD
北大核心
2006年第11期835-837,共3页
China Pharmacy
