摘要
通过对猴模拟下颌支正颌外科手术后骨愈合部位生物力学、组织学和扫描电镜观察 ,探讨术后复发的机理。在对 2 0只猕猴分别施行矢状劈开前徒和斜行切开后徒术后 3、6、12、2 4周标本测定愈合部位的强度和应变特性 ,并进行组织学和扫描电镜观察后 ,发现矢状劈开术后 6周生物力学性能接近对照组 ,12周超过对照组。斜行切开术后 12周生物力学性能接近对照组 ,2 4周超过对照组。矢状劈开术后 6周骨痂钙化明显 ,术后 2 4周已成为成熟骨组织 ;斜行切开术后 6周仍为明显的纤维性骨痂 ,细胞成分明显 ,术后 2 4周成为骨性骨痂 ,但尚未成为成熟骨组织。根据实验结果 ,可以认为矢状劈开术后愈合部位的力学性能恢复及骨痂成熟均较斜行切开术早 ;
The relapse after orthognathic surgery was frequently reported in recent years. But up to now researches concerning bio-mechanic mechanism of relapse are rare. The purpose of this study, by imitating the operation on monkeys, was to examine the biomechanical properties and histological characteristics after operation in order to investigate the mechanism of the relapse after orthognathic surgery. 20 rhesus monkeys divided into two groups were subjected to bilateral sagittal split and oblique osteotomy, respectively. The broken strength, stress and strain of the operated sites were examined with the use of biomechanical methods, and the healing scab was observed using histological method and SEM at 3, 6, 12,24 weeks after operation. The results obtained demonstrated that bone healing and biomechanical properties reached certain level after 6 to 12 weeks' recovery in both operation groups; the biomechanical properties and histological characteristics recovered faster in sagittal split group than in oblique osteotomy group. Histologoical examination also demonstrated similar results. From the data above it is suggested that the higher relapse rate in sagittal split may more closely related to the mechanical effect different from the scab healing, although 8 weeks' fixation may meet the requirement of clinical treatment, accessory fixation method should be adopted after the removal of inter-maxilla fixation.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
2004年第1期47-50,共4页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目 ( 3 90 0 0 10 5 )
