摘要
以氰乙酰胺和 6 苯基己酸为原料 ,用改进了的合成路线 ,通过 9步反应合成母体脂肪酸ω 苯基 β 甲基十五烷酸 (BMPPA) ,并在其基础上合成了ω 苯基 β 甲基对碘十五烷酸(BMIPPA) .同时采用三氟乙酸铊法对BMPPA进行了碘标记 ,成功地制备了1 2 5I BMIPP ,并进行了标记产物的小鼠体内生物分布实验 ,显示了良好的心肌摄取和滞留 .
Fatty acid BMPPA(β-methyl phenyl pentadecanoic acid) is synthesized after nine steps from 2-cyanoacetamide and 6-phenyl-hexanoic acid based on the improved synthesis route. BMIPPA (15-(p-iodophenyl)-3(R,S)-methylpentadeca-noic acid) is synthesized based on the precursor. The iodine-125 labeling of BMPPA is accomplished by the thallation method and 125I-BMIPP is prepared successfully. The result of biodistribution in mice indicates that the labeled product takes on good uptake and retention in myocardium.
出处
《北京师范大学学报（自然科学版）》
CAS
CSCD
北大核心
2004年第1期85-91,共7页
Journal of Beijing Normal University(Natural Science)
关键词
心肌代谢显像剂
碘标记
脂肪酸
ω-苯基β-甲基对碘十五烷酸
ω-苯基β-甲基十五
烷酸
myocardial metabolism imaging agent
radioiodination labeled
fatty acid
15-(p-iodophenyl)-3(R,S)-methylpentadeca-noic acid(BMIPPA)
β-methyl phenyl pentadecanoic acid(BMPPA)
