摘要
目的 :探讨盐酸川芎嗪注射液联合瑞舒伐他汀对短暂性脑缺血发作(TIA)患者血清同型半胱氨酸(Hcy)、脂蛋白相关磷脂酶A2(Lp-PLA2)水平变化及生活质量的影响。方法:选取2015年4月—2017年2月我院收治的82例TIA患者为研究对象,按随机数字表法分为两组,各41例。对照组给予常规治疗,试验组在常规治疗基础上给予盐酸川芎嗪注射液(160～200 mg加入250 mL浓度为0.9%的氯化钠注射液,qd)+瑞舒伐他汀(10 mg,qd)治疗。观察并比较两组治疗效果、血清Hcy、Lp-PLA2水平变化及生活质量。结果:试验组治疗总有效率为92.68%,高于对照组的65.85%,差异有统计学意义(P <0.05);试验组治疗后血清Lp-PLA2、Hcy水平低于对照组,生活质量评分高于对照组,差异有统计学意义(P <0.05)。结论 :盐酸川芎嗪注射液联合瑞舒伐他汀治疗TIA的疗效确切,可降低血清Hcy、Lp-PLA2水平,提高患者的生活质量。
Objective: To investigate the effect of ligustrazine hydrochloride injection combined with rosuvastatin on serum homocysteine (Hcy) and lipoprotein-associated phospholipase A2 (Lp-PLA2) levels and quality of life in the patients with transient ischemic attack (TIA). Methods: 82 cases of TIA patients admitted to our hospital from April 2015 to February 2017 were selected as subjects investigated and randomly divided into two groups. 41 cases in each group. The patients in the control group were given conventional treatment. The patients in the experimental group were given ligustrazine hydrochloride injection (160~200 mg added to 250 mL 0.9% sodium chloride injection, qd) plus rosuvastatin (10 mg, qd) treatment. The therapeutic effects, changes of serum Hcy and Lp-PLA2 levels and quality of life were compared between the two groups. Results: The total effective rate in the experimental group was 92.68%, which was higher than 65.85% in the control group (P<0.05). The levels of serum Lp-PLA2 and Hcy in the experimental group were significantly lower than those in the control group, and the scores of the quality of life in the experimental group was significantly higher than that in the control group (P<0.05). Conclusion: Ligustrazine hydrochloride injection combined with rosuvastatin is effective in the treatment of TIA, and can reduce serum Hcy and Lp-PLA2 levels and improve the quality of life of patients.
作者
计文芳
Ji Wen-fang(Department of Drug Dispensing,General Hospital of Pingmei Shenma Medical Group,Henan Pingdingshan 467000,China)
出处
《中国执业药师》
CAS
2018年第11期87-89,共3页
China Licensed Pharmacist
