摘要
目的:探究培美曲塞联合顺铂与依托泊苷单药同步放化疗治疗局部晚期老年肺腺癌的疗效。方法:选取我院2015年10月-2016年12月收治的70例老年肺腺癌患者,按随机数字表法分为对照组和观察组,两组均给予放射治疗,对照组在放射治疗基础上给予依托泊苷(60~100 mg,qd)治疗,观察组在放射治疗基础上给予培美曲塞[500 mg/(m^2·d)]联合顺铂(75 mg/m^2)治疗。比较两组疗效和不良反应发生率。结果 :观察组缓解率为68.57%,高于对照组的42.86%,差异有统计学意义(P<0.05);观察组不良反应发生率为42.86%显著低于对照组的71.43%,差异有统计学意义(P<0.05)。结论 :培美曲塞联合顺铂治疗局部晚期老年肺腺癌比依托泊苷治疗更安全有效。
Objective:To explore the curative efficacy of pemetrexed combined with cisplatin and etoposide alone with concurrent radiochemotherapy in the treatment of elderly patients with locally advanced lung adenocarcinoma. Methods:70 elderly patients with lung adenocarcinoma admitted in Xinyang Central Hospital of Henan Province from October 2015 to December 2016 were selected and randomly divided to the control group and the observation group, with 35 patients in each group. In addition to the radiation therapy applied in both groups, patients in the control group were treated with etoposide(60~100 mg,qd),while patients in the observation group were treated with pemetrexed [500 mg/(m^2·d)] combined with cisplatin(75 mg/m^2).The effects and the incidence of adverse reactions were compared between the two groups. Results:The remission rate of the observation group was 68.57%, which was higher than that of the control group(42.86%). The difference was statistically significant(P<0.05). The incidence of adverse reaction in the observation group was 42.86%, which was significantly lower than 71.43% of the control group, The difference was staistically signifficant(P<0.05).Conclusion:Pemetrexed combined with cisplatin shows superior efficacy in the treatment of locally advanced lung cancer in elderly than etoposide treatment, with better safety.
出处
《中国执业药师》
CAS
2018年第2期15-17,共3页
China Licensed Pharmacist
关键词
晚期肺腺癌
培美曲塞
顺铂
依托泊苷
放化疗
Advanced Adenocarcinoma of Lung
Pemetrexed
Cisplatin
Etoposide
Radiochemotherapy
