摘要
目的 :研究辛伐他汀联合氨氯地平治疗高血压合并高脂血症患者的疗效,及其对血清炎症状态和血液流变学变化的影响。方法 :选取2014年1月-2016年12月我院门诊及住院部收治的196例高血压合并高脂血症患者为研究对象,采用随机数字表法分为对照组和研究组,各98例。两组患者均给予氨氯地平治疗,研究组加用辛伐他汀,患者均治疗3个月,对比两组疗效及安全性,于治疗前后检查患者的炎症指标及血液流变学指标。结果 :研究组的血压及血脂治疗总有效率均高于对照组(P<0.05);经过治疗后,两组患者超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平明显下降,且研究组下降更显著,差异均有统计学意义(P<0.05);两组患者治疗后血液流变学指标水平明显低于治疗前(P<0.05),其中研究组患者血液流变学各项指标改善更明显(P<0.05);研究组与对照组不良反应发生率比较无统计学差异。结论 :辛伐他汀联合氨氯地平在治疗高血压合并高脂血症患者疗效确切,安全性好,具有改善血压和血脂、降低血清炎性反应的作用,改善血液流变学指标,可推广使用。
Objective:To investigate the clinical curative effect of simvastatin combined with amlodipine on hypertension complicated by hyperlipidemia as well as the influence on the changes of serum inflammatory state and hemorheology. Methods:A total of 196 patients with hypertension complicated by hyperlipidemia in the outpatient and inpatient departments of Zhengzhou First People's Hospital from April 2014 to December 2016 were randomly divided into control and trial groups, 98 for each. The patients in control group were treated with amlodipine, while those in trial group with amlodipine combined with simvastatin, for 3 months. The curative effects and safeties in the two groups were compared, while the indexes of inflammation and hemorheology were examined before and after treatment. Results:The total effective rate on blood pressure and blood lipid in trial group were higher than those in control group(P<0.05). After treatment, the levels of hs-CRP and TNF-α significantly decreased in the two groups, which decreased more significantly in trial group(each P<0.05). The hemorheological indexes of the two groups after treatment were significantly lower than those before treatment(P<0.05), which was improved more significantly in trial group(P<0.05). However, there was no significant difference between the incidences of adverse reactions in the two groups. Conclusion:Simvastatin combined with amlodipine showed definite curative effect on hypertension complicated with hyperlipidemia and was of high safety, which improved the blood pressure and blood lipid, reduced the serum inflammatory reaction, and improved the hemorheology, and was worthy of popularization.
出处
《中国执业药师》
CAS
2017年第5期26-29,共4页
China Licensed Pharmacist
