摘要
目的探讨盐酸氨溴索联合纤维支气管镜肺泡灌洗方案治疗重症肺炎患者的临床效果。方法选取北票市中心医院呼吸科2017年9月至2018年4月收治的100例重症肺炎患者,随机分为对照组与研究组,各50例。对照组采用盐酸氨溴索治疗,研究组则采用盐酸氨溴索联合纤维支气管镜肺泡灌洗治疗。比较两组患者临床疗效、呼吸机带机时间、平均住院时间、治疗1周后急性生理与慢性健康评分(APACHEⅡ)、治疗前后外周血清炎症介质水平、多器官脏器衰竭发生率以及死亡率。结果研究组临床疗效优于对照组(P<0.05);治疗后,研究组外周血清炎症介质水平优于对照组(P<0.05);研究组呼吸机带机时间、平均住院时间、治疗1周APACHEⅡ评分优于对照组(均P<0.05);研究组多器官脏器衰竭发生率以及死亡率均低于对照组(均P<0.05)。结论盐酸氨溴索联合纤维支气管镜肺泡灌洗治疗重症肺炎效果显著,可有效减轻患者炎症反应,降低死亡率,提高患者预后质量。
Objective To explore the efficacy of ambroxol hydrochloride combined with fiberoptic bronchoscopic alveolar lavage in patients with severe pneumonia.Methods A total of 100 patients with severe pneumonia admitted to the respiratory department of Beipiao Central Hospital from September 2017 to April 2018 were selected and randomly divided into control group and study group,with 50 cases in each group.The control group was treated with ambroxol hydrochloride,while the study group was treated with ambroxol hydrochloride combined with fiberoptic bronchoscopic alveolar lavage.The clinical efficacy,time of ventilator use,average hospitalization time,acute physiology and chronic health score(APACHE II)after 1-week treatment,peripheral serum levels of inflammatory mediators,incidence of multiple organ failure and mortality were compared between the 2 groups.Results The clinical efficacy in the study group was better than that in the control group(P<0.05).After the treatment,the peripheral serum levels of inflammatory mediators in the study group were better than those in the control group(P<0.05).The time of ventilator use,average hospitalization time,and APACHE II score of the study group were better than those of the control group(P<0.05).The incidence of multiple organ failure and mortality in the study group were lower than those in the control group(P<0.05).Conclusion Ambroxol hydrochloride combined with fiberoptic bronchoscopic alveolar lavage is effective in the treatment of severe pneumonia.It can effectively alleviate inflammation,reduce mortality and improve the quality of prognosis for patients.
作者
刘永生
LIU Yong-Sheng(Department of Respiration,Beipiao Central Hospital,Chaoyang 122100,China)
出处
《中国药物经济学》
2019年第6期80-82,共3页
China Journal of Pharmaceutical Economics
关键词
重症肺炎
盐酸氨溴索
纤维支气管镜肺泡灌洗方案
有效性
Severe pneumonia
Ambroxol hydrochloride
Fiberoptic bronchoscopic alveolar lavage
Effectiveness