摘要
[目的]对广东地区腺瘤性息肉(adenomatous polyps,APs)发病危险因素及中医发病机制进行分析。[方法]选取2017年8月~2018年8月于广州中医药大学第二附属医院消化科住院且诊断为结直肠息肉的本地患者643例,收集患者的临床资料进行横断面-回顾性分析。[结果]APs发病与性别有关(OR=0.67,95%CI:0.48~0.96,P=0.027),男性APs发病率(54.4%)大于女性(45.6%)。APs患者脾虚夹瘀证最常见(74.3%),其次为脾胃气虚证(10.2%)和大肠湿热证(8.6%);男性APs患者以脾虚夹瘀证(72.4%)和大肠湿热证(13.4%)多见,女性则以脾虚夹瘀证(76.7%)和脾胃气虚证(10.7%)多见。APs发病与气虚夹瘀浊、瘀血致病因素有关(P=0.001)。[结论]性别为APs发病的危险因素。脾虚夹瘀证是广东地区APs的基础证型,而男女之间中医证型主要分布存在差异。广东地区APs的发病机制为脾虚为本,瘀浊、瘀血为标,虚实夹杂为患。
[Objective]To analyze the risk factors of adenomatous polyps in Guangdong and the pathogenesis of TCM.[Methods]A total of 643 local patients who were hospitalized in the Department of Gastroenterology,the Second Affiliated Hospital of Guangzhou University of Chinese Medicine from August 2017 to August 2018 and diagnosed with colorectal polyps were enrolled.The clinical date of 643 patients were collected for cross-sectional retrospective analysis.[Results]Adenomatous polyps incidence was related to gender(OR=0.67,95%CI:0.48~0.96,P=0.027).The incidence of adenomatous polyps in males(54.4%)was higher than that of females(45.6%).Among the adenomatous polyps,the spleen deficiency with blood stasis syndrome was the most(74.3%),followed by the spleen and stomach qi deficiency syndrome(10.2%)and the large intestine damp-heat syndrome(8.6%).Male patients of adenomatous polyps were mainly found in spleen deficiency with blood stasis syndrome(72.4%)and large intestine damp-heat syndrome(13.4%),while women were more common with spleen deficiency with blood stasis syndrome(76.7%)and spleen and stomach qi deficiency syndrome(10.7%).The incidence of APs was associated with qi deficiency with turbid and blood stasis(P=0.001).[Conclusion]Gender is a risk factor for the onset of APs.Spleen deficiency with blood stasis syndrome is the basic syndrome type of APs in Guangdong,and there are differences in the main distribution of TCM syndromes between men and women.The main TCM pathogenesis of APs in Guangdong area is spleen-deficiency-based,with turbid and blood stasis,intermingled deficiency and excess.
作者
毛文昕
钟子劭
黄穗平
张望
王静
MAO Wen-xin;ZHONG Zi-shao;HUANG Sui-ping;ZHANG Wang;WANG Jing(The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou510405,China;Department of Gastroenterology,The Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou510120,China)
出处
《中国中西医结合消化杂志》
CAS
2019年第10期726-729,734,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家自然科学基金项目(No:81703995)
广东省中医院院内专项项目(No:YN2015MS24)
