期刊文献+

冰片对脑部疾病作用机制的研究进展 被引量:7

Mechanism of Borneolum Syntheticum Effect on Central Nervous and Vascular System Diseases
原文传递
导出
摘要 在传统中医药中,芳香开窍类的代表药物冰片常以'佐使'的功效广泛应用于神志类疾病的临床治疗。近年来,国内外很多学者通过对冰片的有效成分和药理作用进行深入的研究与分析,认为冰片的单独应用对于脑部疾病的作用显著。本文主要围绕冰片对脑循环系统以及中枢神经系统的作用机制展开论述。在抑制脑损伤方面,冰片可以降低神经元以血管内皮损伤,减轻脑水肿状态,降低缺血侧脑组织中Ca2+的含量;在抗炎方面,冰片可以降低诱导型一氧化氮合酶(i NOS)和肿瘤坏死因子-α(TNF-α)的表达,减少白细胞浸润的数目、减少细胞间黏附分子-1(ICAM-1)阳性血管数和TNF-α阳性细胞数;在调节血脑屏障方面,冰片可提高微血管内皮细胞上紧密连接蛋白-1(ZO-1)和紧密连接因子-5(claudin-5)蛋白的表达量;冰片透皮吸收的强弱,可能与其构型、抽提脂质的能力以及亲水性相关;冰片提高他药的生物利用度的作用,在临床应用比较广泛;冰片的鼻内给药可绕过血脑屏障(BBB),直达脑部中枢神经,在治疗脑血管病方面具有良好前景;在癫痫、阿尔茨海默病等脑部疾病的治疗方面,冰片的作用机制与其对各类脑神经递质如γ-氨基丁酸(GABA),甘氨酸(GLY),天冬氨酸(ASP)及谷氨酸(GLU),β-内啡肽(β-EP),去甲肾上腺素(NE),肾上腺素(E),5羟色胺(5-HT),多巴胺(DA)等密切相关,然而实验结果不尽相同,可能与冰片的不同给药剂量和时间有关,尚待研究。 In traditional Chinese medicine,Borneolum Syntheticum,a representative drug of aromatic orifice,is often widely used in the clinical treatment of neurotic diseases.In recent years,many scholars at home and abroad have studied and analyzed the effective components and pharmacological effects of Borneolum Syntheticum,and it is considered that Borneolum Syntheticum alone has a significant effect on brain diseases.In this paper,the mechanism of Borneolum Syntheticum on cerebral circulatory system and central nervous system is discussed.In inhibiting brain injury,Borneolum Syntheticum can reduce neuronal vascular endothelial injury,reduce brain edema and decrease the content of Ca2+in ischemic brain tissue.In the aspect of anti-inflammation,Borneolum Syntheticum can reduce the expression of induced nitric oxide synthase(i NOS)and tumor necrosis factor-α(TNF-α),the number of leukocyte infiltration,the number of intercellular adhesion molecule-1(ICAM-1)positive vessels and the number of TNF-αpositive cells.In regulating the blood-brain barrier,Borneolum Syntheticum can increase the expression of zonula occluden-1(ZO-1)and claudin-5 protein in microvascular endothelial cells.The strength of the transdermal absorption of the Borneolum Syntheticum may be related to its configuration,the ability to extract the lipid,and the hydrophilicity.The effect of Borneolum Syntheticum on improving the bioavailability of other drugs is widely used in clinic.Nasal administration of Borneolum Syntheticum can bypass blood-brain barrier(BBB),and reach the central nervous system of the brain.It has a good prospect in the treatment of cerebrovascular disease.In the treatment of brain diseases such as seizures and Alzheimer’s disease,the mechanism of Borneolum Syntheticum is closely related to its effect on various brain neurotransmitters such asγ-aminobutyric acid(GABA),glycine acid(GLY),D-aspartic acid(ASP),glutamic acid(GLU),β-endorphin(β-EP),norepinephrine(NE),epinephrine(E),5-hydroxytryptamine(5-HT),dopamine(DA).However,the exper
作者 谭东宇 王静宇 康伟聪 杨阳 杨桢 TAN Dong-yu;WANG Jing-yu;KANG Wei-cong;YANG Yang;YANG Zhen(College of Basic Medicine,Hebei University of Chinese Medicine,Shijiazhuang 050200,China;College of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China)
出处 《中国实验方剂学杂志》 CAS CSCD 北大核心 2019年第21期212-219,共8页 Chinese Journal of Experimental Traditional Medical Formulae
基金 国家自然科学基金项目(81573847) 河北省中医药管理局专项课题
关键词 冰片 中枢神经系统 脑循环系统 非选择性阳离子通道 综述 机制 Borneolum Syntheticum central nervous system cerebral circulatory system nonselective cation channel review mechanism
  • 相关文献

参考文献39

二级参考文献391

共引文献407

同被引文献128

引证文献7

二级引证文献13

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部