摘要
近几年我国艾滋病病毒1型(HIV-1)的流行情况复杂,性接触传播逐渐成为感染HIV-1的最主要途径。CRF01_AE毒株在中国部分地区所占比例呈现逐年上升趋势,且与性传播密切相关,尤其在男男同性性行为者中广泛流行。本文对46篇针对CRF01_AE亚型研究的文献进行了综述,总结了我国HIV-1流行情况,并对我国黑龙江、河北、江苏、浙江、广西、广东、上海地区的HIV-1 CRF01_AE流行情况进行汇总,获得2004-2015年CRF01_AE亚型在HIV-1感染者基因亚型中所占比例变化规律,并分析了此毒株流行情况变化的原因。CRF01_AE毒株的快速传播和广泛分布为我国HIV-1感染的防控带来了挑战,在今后的防控工作中应密切关注该亚型毒株的变化情况。
In recent years,the HIV-1 epidemic in China becomes more and more complicated,HIV-1 transmission via sexual contact increased year by year and has turned to be the major infection route in China.The proportion of CRF01_AE strains in partial areas of China has been increasing,and CRF01_AE epidemic is closely associated with sexual contact transmission of HIV-1,especially homosexual contact among men who have sex with men(MSM).In this review,we summarize 46 published literatures on CRF01_AE subtypes to understand the epidemic status of HIV-1 in China with focus on HIV-1 CRF01_AE strains in Heilongjiang,Hebei,Jiangsu,Zhejiang,Guangxi,Guangdong and Shanghai to analyze the change patterns of CRF01_AE subtype from 2004 to 2015.Fast transmission and wide distribution of CRF01_AE virus bring great challenges to the prevention and treatment of HIV-1 infections in China.
作者
霍青青
李庆海
刘思宇
于冬艺
王福祥
陈晓红
HUO Qing-qing;LI Qing-hai;LIU Si-yu;YU Dong-yi;WANG Fu-xiang;CHEN Xiao-hong(Department of Infectious Diseases,the Fourth Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001,China;不详)
出处
《中国病毒病杂志》
CAS
2019年第3期236-241,共6页
Chinese Journal of Viral Diseases
基金
国家自然科学基金面上项目(81672003)
国家“十三五”艾滋病和病毒性肝炎等重大传染病防治科技重大专项(2017ZX10202102
2018ZX10302104-001-005)
黑龙江省自然科学基金项目面上项目(C2017043)
