摘要
目的研究射频消融术对于阵发性房颤患者血清成纤维细胞生长因子-21(FGF-21水平及心功能的影响。方法选取青岛市中心医院2015年11月至2017年12月收治的阵发性房颤患者80例,采用随机数字表法分为治疗组40例和对照组40例;对照组采取药物治疗,治疗组采取射频消融术治疗,术后6个月采用独立样本t检验比较治疗组与对照组左心房内径(LAD)、右心房内径(RAD)、左心室射血分数(LVEF)以及血清FGF-21水平的差异。结果治疗组的LAD、RAD小于对照组[(36.2±7.5)mm vs (42.5±8.3)mm;(35.3±7.2)mm vs (39.4±8.1)mm],LVEF高于对照组[(59.3±8.2)%vs (52.1±7.5)%],差异均具有统计学意义(t=3.586,P <0.001;t=2.393,P=0.019;t=4.098,P <0.001)。治疗组血清FGF-21水平低于对照组[(145.2±25.6)ng/L vs (197.6±30.4)ng/L],差异具有统计学意义(t=4.879,P <0.001)。结论射频消融术可明显降低血清FGF-21水平,改善患者心功能;血清FGF-21水平对房颤患者预后有一定预测价值。
Objective To investigate the effect of radiofrequency ablation on serum FGF-21 level and cardiac function in patients with paroxysmal atrial fibrillation. Methods Eighty patients with paroxysmal atrial ?brillation treated at Qingdao Central Hospital from November 2015 to December 2017 were randomly divided into either a treatment group(40 cases) or a control group(40 cases). The control group was given comprehensive drug therapy, and the treatment group underwent RF ablation therapy. The two groups of patients were compared for left atrial diameter(LAD), right atrium diameter(RAD), left ventricular ejection fraction(LVEF%), and serum FGF-21 levels. Results LAD and RAD were signi?cantly smaller in the treatment group than in the control group [(36.2±7.5) mm vs(42.5±8.3) mm, t=3.586, P< 0.001;(35.3±7.2) mm vs(39.4±8.1) mm, t=2.393, P=0.019], and LVEF% was signi?cantly better in the treatment group than in the control group ((59.3±8.2)% vs(52.1±7.5)%, t=4.098, P < 0.001)Seum FGF-21 level in the treatment group was signi?cantly lower than that of the control group ((145.2±25.6) ng/L vs(197.6±30.4) ng/L, t=4.879, P < 0.001)Conclusion Radiofrequency ablation can signi?cantly decrease serum FGF-21 level and improve the heart function of patients with paroxysmal atrial fibrillation. Serum FGF-21 level may predict the cardiac function of patients with paroxysmal atrial ?brillation.
作者
王燕
徐丹
刘丽伟
王玉宏
Wang Yan;Xu Dan;Liu Liwei;Wang Yuhong(Department of Cardiology,Qingdao Central Hospital,Qingdao 266042,ChinaPhysical Examination Center,Qingdao Central Hospital,Qingdao 266042,China;Emergency Center,Qingdao Central Hospital,Qingdao 266042,China)
出处
《中华临床医师杂志（电子版）》
CAS
2018年第12期669-672,共4页
Chinese Journal of Clinicians(Electronic Edition)
关键词
射频消融术
阵发性房颤
成纤维细胞生长因子-21
心功能
Radiofrequency ablation
Paroxysmal atrial fibrillation
Fibroblast growth factor-21
Cardiac function
