摘要
目的:探究厄贝沙坦在高血压合并阵发性房颤患者中的疗效及对心率变异性的影响。方法:将2020年1月—2021年10月北京市昌平区中西医结合医院收治的100例高血压合并阵发性房颤患者根据随机数字表法分为对照组(n=50)和观察组(n=50)。对照组采用氨氯地平联合胺碘酮进行治疗,观察组则采用厄贝沙坦联合胺碘酮进行治疗。比较两组治疗总有效率、治疗前后的血压水平、左心房内径(LAD)、P波最大时限(P_(max))、P波离散度(Pd)及心率变异性指标[相邻NN之差>50 ms的个数占总窦性心搏个数的百分比(PNN50)、RR间期平均值标准差(SDANN)及相邻RR间期差值的均方根(RMSSD)]。结果:观察组治疗总有效率显著高于对照组,差异有统计学意义(P<0.05)。治疗前两组血压水平、LAD、P_(max)、Pd及心率变异性指标比较,差异均无统计学意义(P>0.05);治疗6、12个月后,两组血压水平、LAD、P_(max)、Pd及心率变异性指标均显著优于治疗前,且观察组的血压水平、LAD、P_(max)及Pd均显著低于对照组,心率变异性指标均显著高于对照组,差异均有统计学意义(P<0.05)。结论:厄贝沙坦在高血压合并阵发性房颤患者中的疗效较好,可显著改善患者的心率变异性。
Objective:To investigate the effect of Irbesartan in patients with hypertension complicated with paroxysmal atrial fibrillation and its influence on heart rate variability.Method:A total of 100 patients with hypertension complicated with paroxysmal atrial fibrillation treated in Beijing Changping District Integrated Traditional Chinese and Western Medicine Hospital from January 2020 to October 2021 were divided into control group(n=50)and observation group(n=50)according to random number table method.The control group was treated with Amlodipine combined with Amiodarone,and the observation group was treated with Irbesartan combined with Amiodarone.The total effective rate,before and after treatment of blood pressure levels,left atrial diameter(LAD),the P-wave maximum duration(P_(max)),P-wave dispersion(Pd)and heart rate variability indexes[percentage of successive NN intervals>50 ms(PNN50),standard deviation of the averages of normal-to-normal intervals(SDANN)and root mean square of successive RR differences as time-domain analysis(RMSSD)]were compared between the two groups.Result:The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in blood pressure levels,LAD,Pmax,Pd and heart rate variability indexes between the two groups(P>0.05).After 6 and 12 months of treatment,the blood pressure levels,LAD,P_(max),Pd and heart rate variability indexes of the two groups were significantly better than those before treatment,the blood pressure levels,LAD,P_(max) and Pd of the observation group were significantly lower than those of the control group,and the heart rate variability indexes of the observation group were significantly higher than those of the control group,the differences were statistically significant(P<0.05).Conclusion:Irbesartan is effective in patients with hypertension complicated with paroxysmal atrial fibrillation,and can significantly improve th
作者
张钿
金钊
ZHANG Dian;JIN Zhao(Beijing Changping District Integrated Traditional Chinese and Western Medicine Hospital,Beijing 102208,China;不详)
出处
《中国医学创新》
CAS
2023年第23期115-118,共4页
Medical Innovation of China
关键词
厄贝沙坦
高血压
阵发性房颤
心率变异性
Irbesartan
Hypertension
Paroxysmal atrial fibrillation
Heart rate variability
