摘要
目的:综合评价中国汉族女性血清脂联素(adiponectin)水平与多囊卵巢综合征(polycystic ovarian syndrome,PCOS)的相关性。方法:制定相关检索策略,检索2014年12月以前公开发表于中国学术期刊全文数据库(CNKI)、中国维普数据库、中国万方数据库、中国生物医学文献、Pub Med、荷兰医学文摘(EMbase)等数据库中所有关于中国汉族女性脂联素与PCOS相关性的病例对照研究。按纳入排除标准筛选文献并评价纳入研究质量后,应用Rev Man 5.0软件进行Meta分析。结果:共纳入17个病例对照研究,其中PCOS患者1 045例,对照组659例。Meta分析结果显示,PCOS组血清脂联素水平低于对照组(WMD=-4.10,95%CI=-5.79^-2.40,Z=4.73,P<0.000 01);正常体质量PCOS组脂联素水平低于正常体质量对照组(WMD=-2.00,95%CI=-2.28^-1.71,Z=13.79,P<0.000 01);超重/肥胖PCOS组血清脂联素水平低于正常体质量PCOS组(WMD=1.63,95%CI=0.91~2.36,Z=4.41,P<0.000 1),也低于超重/肥胖对照组(WMD=-1.64,95%CI=-2.06^-1.22,Z=7.61,P<0.000 01)。结论:中国汉族女性PCOS患者血清脂联素水平低,其可作为PCOS患者独立于超重/肥胖的一个影响因素。
Objective: To evaluate the association of serum adiponectin concentrations with polycystic ovarian syndrome( PCOS) in Chinese Han women. Methods: By formulating the retrieval strategy,papers related to the association of serum adiponectin concentrations with PCOS in Chinese Han women published before the December in 2014 were retrieved from CNKI,VIP,Wanfang,CBM,Pub Med,EMbase and so on. The paper screened was based on the inclusion / exclusion criteria. Rev Man 5. 0 software was used for the Meta-analysis. Results: Seventeen studies were included,with 1 045 cases of PCOS and 659 non-PCOS subjects. Meta-analysis results showed that( 1) Patients with PCOS had lower serum adiponectin concentrations than the control group( WMD =- 4. 10,95% CI =- 5. 79-- 2. 40,Z = 4. 73,P < 0. 000 01);( 2) the PCOS patients with normal weight( BMI < 25 kg /m2) had lower serum adiponectin concentrations than normal weight control group( WMD =- 2. 00,95% CI =- 2. 28-- 1. 71,Z = 13. 79,P < 0. 000 01);( 3) the over weight/obesity PCOS patients( BMI≥25 kg /m2) had lower serum adiponectin levels than both the normal weight PCOS group( WMD = 1. 63,95% CI = 0. 91- 2. 36,Z = 4. 41,P < 0. 000 1),and the over weight / obesity control group( WMD =- 1. 64,95% CI =- 2. 06-- 1. 22,Z = 7. 61,P < 0. 000 01),respectively. Conclusion: Adiponectin concentration was significantly lower in Chinese Han women with PCOS,which might be used as an independent factor of overweight / obesity for PCOS.
出处
《江苏大学学报（医学版）》
CAS
2015年第3期229-235,共7页
Journal of Jiangsu University：Medicine Edition
基金
国家自然科学基金资助项目(81372798)
