摘要
目的探究血清心肌酶和脑脊液(Cerebrospinal Fluid,CSF)中乳酸脱氢酶(lactate dehydrogenase,LDH)和肿瘤坏死因子-α(TNF-α)对成年患者颅内感染的诊断效果。方法选取2016年1月-2018年1月医院收治的颅内感染患者67例设为研究组,选取同期73名成年体检健康者为对照组,测定所有研究对象的血清中LDH、谷草转氨酶(Aspartate aminotransferase AST)、肌酸激酶(Creatine Kinase,CK)、CSF中LDH、TNF-α水平,分析研究组患者颅内感染的类型并对不同感染类型患者以上指标进行比较。结果研究组患者血清LDH、AST和CK分别为(232.71±71.43)U/L、(36.12±16.95)U/L和(310.65±96.44)U/L高于对照组(P<0.05);研究组患者CSF中LDH和TNF-α分别为(204.82±87.36)U/L和(21.37±10.62)pg/ml高于对照组(P<0.05);化脓型患者血清LDH为(191.73±58.82)U/L均低于结核型及病毒型患者,CSF中LDH、TNF-α分别为(37.65±13.42)U/L、(327.65±104.31)pg/ml均高于结核型及病毒型患者,病毒型患者CSF中LDH为(18.43±7.68)U/L低于结核型患者,病毒型患者CK为(374.25±124.61)U/L均高于化脓型及结核型患者(P<0.05)。结论 LDH、AST、CK、CSF中LDH、TNF-α能为颅内感染的诊断和治疗提供参考依据,其中CSF中LDH、TNF-α对于化脓性脑膜炎及病毒性脑膜炎患者的早期诊断和鉴别诊断具有重要意义。
OBJECTIVE To explore the diagnostic efficacy of serum myocardial enzymes and LDH,TNF-αin cerebrospinal fluid(CSF)on intracranial infection in adult patients.METHODS Sixty-seven patients with intracranial infection admitted to our hospital from Jan.2016 to Jan.2018 were selected as the study group,and 73 healthy adults in the same period were selected as the control group.The serum lactate dehydrogenase(LDH),aspartate aminotransferase(AST),creatine kinase(CK),and the LDH and TNF-a levels in CSF were determined.The types of intracranial infection were analyzed in the study group and the above indicators were compared for patients with different infection types.RESULTS The serum LDH,AST and CK levels in the study group were(232.71±71.43)U/L,(36.12±16.95)U/L and(310.65±96.44)U/L,respectively,significantly higher than those in the control group(P<0.05).The LDH and TNF-a levels in the study group were(204.82±87.36)U/L and(21.37±10.62)pg/ml,respectively,significantly higher than those in the control group(P<0.05).The LDH level in the purulent patients was(191.73±58.82)lower than those in tuberculosis and viral type patients.The LDH and TNF-a levels in CSF were(37.65±13.42)U/L and(327.65±104.31)pg/ml,higher than those in tuberculosis and viral type patients,and the LDH level in viral type patients was(18.43±7.68)U/L,higher than that in tuberculosis patients.The CK level in viral type patients was(374.25±124.61)U/L,significantly higher than that in purulent and tuberculosis patients(P<0.05).CONCLUSION Serum LDH,AST,CK,and LDH,TNF-αin CSF can provide reference for the diagnosis and treatment of intracranial infection in adult patients.Among them,LDH and TNF-αin CSF can be used for early diagnosis and differential diagnosis in patients with purulent meningitis and viral meningitis.
作者
李林艳
陈嫩梅
张玉巧
张雪莹
LI Lin-yan;CHEN Nen-mei;ZHANG Yu-qiao;ZHANG Xue-ying(Luoyang Central Hospital Affiliated to Zhengzhou University,Luoyang,Henan 471000,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2019年第11期1643-1646,共4页
Chinese Journal of Nosocomiology
基金
国家自然科学基金资助项目(83622789)
洛阳市医药卫生科技发展计划基金资助项目(2017268)
关键词
血清心肌酶
脑脊液
成年患者
颅内感染
Serum myocardial enzymes
Cerebrospinal fluid
Adult patients
Intracranial infection
