摘要
目的探讨母血细胞髓样细胞触发受体(TREM)和CD_(64)对新生儿感染的预测价值。方法选择2017年5月-2017年7月之间在医院产科分娩的773名产妇及新生儿的数据资料进行分析,按照新生儿在出生1周内是否发生感染分组,分析感染新生儿与未感染新生儿的各类指标,对母血TREM和CD_(64)的变化对胎膜早破时早期新生儿感染的预测价值进行分析。结果感染新生儿对应的母血C-反应蛋白(CRP)[(4.26±1.06)mg/l]VS[(5.04±0.88)mg/l],白细胞介素-6(IL-6)[(316.98±28.51)ng/l]VS[(345.50±36.73)ng/l],TREM[(5.19±1.32)MFI]VS[(7.89±1.54)MFI]和CD_(64)[(3.64±1.12)MFI]VS[(5.05±1.36)MFI]的浓度数据均高于非感染组新生儿对应的母血(P <0.05),CRP,IL-6,TREM和CD_(64)对于新生儿感染的曲线AUC分别为0.713,0.735,0.900和0.797,TREM和CD_(64)的诊断价值高于CRP和IL-6,利用CRP,IL-6,TREM和CD_(64)进行新生儿是否发生感染的判别函数计算,交叉验证判别正确率为91.85%。结论母血TREM与CD_(64)对于胎膜早破时新生儿发生感染的预测价值较高,值得在临床工作中运用。
OBJECTIVE To explore the value of triggering receptor expressed on myeloid cells(TREM)and CD64 in prediction of infection in neonates.METHODS The data of 773 puerpera who gave birth in obstetrics department from May 2017 to Jul 2017 and neonates were analyzed,and the neonates were grouped based on the status of infection within 1 week of birth,the indexes of the neonates with infection and the neonates without infection were observed,and the value of maternal blood TREM and CD64 in prediction of early neonatal infection was analyzed.RESULTS The levels of maternal blood C-reactive protein(CRP),interleukin-6(IL-6),TREM and CD64 of the neonates with infection were respectively(4.26±1.06)mg/l,(316.98±28.51)ng/l,(5.19±1.32)MFI and(3.64±1.12)MFI,sighificantly higher than(5.04±0.88)mg/l,(345.50±36.73)ng/l,(7.89±1.54)MFI and(5.05±1.36)MFI of the neonates without infection(P<0.05).The AUCs of CRP,IL-6,TREM and CD64 in prediction of neonatal infection were respectively 0.713,0.735,0.900 and 0.797,the diagnostic value of TREM and CD64 was higher than that of CRP and IL-6.CRP,IL-6,TREM and CD64 to were used to calculate the discriminant function for whether the neonates were infected,and the correct rate of cross-validation was 91.85%.CONCLUSIONThe maternal blood TREM and CD64 have high value in prediction of the neonatal infection of the puerpera with premature rupture of fetal membranes and are worthy to be promoted in the hospital.
作者
丘峻朝
陈海英
何青
黄婵
QIU Jun-chao;CHEN Hai-ying;HE Qing;HUANG Chan(The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong510700,China)
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2019年第5期764-766,775,共4页
Chinese Journal of Nosocomiology
基金
广东省医学科学技术研究基金资助项目(A2015359)
关键词
胎膜早破
新生儿感染
宫内感染
Premature rupture of fetal membrane
Neonatal infection
Intrauterine infection
