摘要
目的:探讨基质金属蛋白酶9(MMP-9)、降钙素原(PCT)、可溶性髓样细胞表达触发因子受体1(sTREM-1)及可溶性白细胞分化抗原14(sCD14)在胎膜早破(PROM)产妇中表达水平,及对并发绒毛膜羊膜炎的预测价值。方法:选择滕州市中心人民医院2016年1月至2017年6月收治的PROM产妇132例纳入研究(PROM组),分为早发PROM组(孕周<37周,58例)和足月PROM组(孕周>37周,74例);选择同期足月健康产妇106例(对照组)。根据是否合并绒毛膜羊膜炎,PROM组产妇分为感染组(51例)和非感染组(81例)。分析MMP-9、PCT、sTREM-1及sCD14在两组产妇表达差异及对PROM并发宫内绒毛膜羊膜炎的诊断效能。结果:PROM组MMP-9[(271.42±34.16)ng/L]、PCT[(54.57±8.16)pg/mL]、sTREM-1[(0.51±0.11)ng/mL]及sCD14[(60.23±9.49)]ng/mL]表达均明显高于对照组[(54.97±10.08)ng/L、(26.04±1.98)pg/mL、(0.19±0.04)ng/mL、(42.04±10.33)ng/mL](t=27.064、13.767、14.831、-13.342,均P<0.01);早发PROM组MMP-9[(314.05±45.37)ng/L]、PCT[(0.61±0.18)ng/mL]、sTREM-1[(63.12±10.12)pg/mL]及sCD14[(68.07±11.05)ng/mL]表达均明显高于足月PROM组[(238.01±40.45)ng/L、(47.87±8.90)pg/mL、(0.43±0.14)ng/mL、(54.09±10.33)ng/mL](t=9.103、8.862、-10.538、6.494,均P<0.05);PROM感染组MMP-9[(343.74±43.74)ng/L]、PCT[(69.88±8.83)pg/mL]、sTREM-1[(0.67±0.16)ng/mL]、sCD14[(70.41±8.89)ng/mL]均明显高于非感染组[(230.09±49.82)ng/L]、[(45.82±11.04)pg/mL]、[(0.42±0.19)ng/mL]、[(54.41±12.42)ng/mL](t=23.655、12.014、9.382、11.306,均P<0.001);联合检测对PROM合并绒毛膜羊膜炎诊断的敏感性(94.23%)、特异性(93.75%)、阳性预测值(92.45%)、阴性预测值(96.20%)均较其他指标单测明显提高(均P<0.05)。结论:MMP-9、PCT、sTREM-1及sCD14联合检测可作为早期胎膜早破并发绒毛膜羊膜炎有效辅助诊断指标。
Objective To investigate the expression levels of matrix metalloproteinase-9(MMP-9),procalcitonin(PCT),soluble triggering receptor expressed on myeloid cells(sTREM-1)and soluble cell differentiation 14(sCD14)in pregnant women with premature rupture of membranes(PROM)and their predictive value for chorioamnionitis.Methods A total of 132 pregnant women with PROM who received treatment in Tengzhou Central People's Hospital from January 2016 to June 2017 were included in the study group.These women were assigned to pre-term PROM group(gestational age<37 weeks,n=58)and full-term PROM group(gestational age>37 weeks,n=74).A total of 106 concurrent full-term healthy pregnant women were included in the control group.Pregnant women in the PROM group were also assigned into an infection group(n=51)and a non-infection group(n=81).Serum levels of MMP-9,PCT,sTREM-1 and sCD14 were compared between study and control groups,and their value in the diagnosis of PROM complicated with chorioamnionitis was analyzed.Results The expression levels of MMP-9[(271.42±34.16)ng/L],PCT[(54.57±8.16)pg/mL],sTREM-1[(0.51±0.11)ng/mL]and sCD14[(60.23±9.49)ng/mL]in the study group were significantly higher than those in the control group[(54.97±10.08)ng/L,(26.04±1.98)pg/mL,(0.19±0.04)ng/mL,(42.04±10.33)ng/mL,t=27.064,13.767,14.831,-13.342,all P<0.01).The expression levels of MMP-9[(314.05±45.37)ng/L],PCT[(0.61±0.18)ng/mL],sTREM-1[(63.12±10.12)pg/mL]and sCD14[(68.07±11.05)ng/mL]in the pre-term PROM group were significantly higher than those in the full-term PROM group[(238.01±40.45)ng/L,(47.87±8.90)pg/mL,(0.43±0.14)ng/mL,(54.09±10.33)ng/mL,t=9.103,8.862,-10.538,6.494,all P<0.05).The expression levels of MMP-9[(343.74±43.74)ng/L],PCT[(69.88±8.83)pg/mL],sTREM-1[(0.67±0.16)ng/mL],sCD14[(70.41±8.89)ng/mL]in the infection group were significantly higher than those in the non-infection group[(230.09±49.82)ng/L,(45.82±11.04)pg/mL,(0.42±0.19)ng/mL and(54.41±12.42)ng/mL,t=23.655,12.014,9.382,11.306,all P<0.01].The sensitivity(94.23%),s
作者
谢斌
孙卓浩
黄友敏
黄潇
赵建明
杨刚
鲁琳琳
Xie Bin;Sun Zhuohao;Huang Youmin;Huang Xiao;Zhao Jianming;Yang Gang;Lu Linlin(Department of Laboratory Medicine,Tengzhou Central People's Hospital,Tengzhou 277599,Shandong Province,China;Department of Endocrinology,Tengzhou Central People's Hospital,Tengzhou 277599,Shandong Province,China;Department of Clinical Medicine,Shandong First Medical University,Tai'an 271016,Shandong Province,China;Department of Clinical Medicine,Qingdao University,Qingdao 266071,Shandong Province,China;Department of Obstetrics and Gynecology,Tengzhou Central People's Hospital,Tengzhou 277500,Shandong Province,China)
出处
《中国基层医药》
CAS
2021年第4期538-542,共5页
Chinese Journal of Primary Medicine and Pharmacy
