摘要
目的采用Meta分析的方法对国内外已公开发表的关于中西药联合治疗流行性角膜结膜炎(EKC)的临床疗效进行系统评价,为临床治疗EKC提供参考。方法检索Pub Med、MEDLINE、中国知网、万方数据库、维普数据库及中国生物医学文献数据库中收录的中西药联合治疗EKC的中、英文文献。依据纳入与排除标准筛选文献,对纳入研究的数据进行提取,将采用中西药联合治疗的患者作为治疗组,采用西药治疗的患者作为对照组。按照Meta分析的要求对检索到的文献进行质量评估,并采用Review Manager 5.3软件对纳入的研究进行Meta分析,评价中西药联合治疗EKC的临床疗效。采用修改后的Jadad质量记分法对纳入文献进行质量评价。各研究间采用卡方检验进行异质性检验,若P>0.05,表示同质性较好,采用固定效应模型;否则采用随机效应模型计算合并效应量。总有效率采用相对危险度(OR)及95%可信区间表示。结果共纳入符合标准的文献7篇,共包含520例(1022只眼)患者,其中,治疗组553只眼,对照组469只眼。7篇文献均比较了治疗组与对照组EKC患者的治疗总有效率,经异质性检验,I^2=15%,P>0.05,提示同质性良好,故采用固定效应模型进行Meta分析。结果显示两组差异有显著统计学意义(OR=9.00,95%可信区间:4.53~17.89,Z=6.27;P<0.05),说明中西药联合组与西药组总体相比,中西药联合治疗的方式疗效更好。结论中西药联合治疗EKC相对于单纯的西药治疗有较显著的优势。
Objective System evaluation about the clinical efficacyof combining traditional Chinese and western medicine for epidemic keratoconjunctivitispublished at home and abroad by the method of Meta analysis,and provide reference for clinicaltreatment of EKC. Methods Through the collection of Pub Med,MEDLINE,China retrieval CNKI, Wanfang database, VIP database and China biomedical literature database of Chinese medicine combined with western medicine in the treatment of EKC related Chinese and English literature. According to the inclusion and exclusion criteria,the literature was extracted,and the data of the study were extracted. The combination of Chinese medicine and Western medicine was used as the treatment group,and Western medicine treatment as the control group. According to the requirement of the Meta analysis to evaluate the quality of the literature retrieved,and use the Rev Man5. 3 for researching according to the Meta analysis,evaluation of the clinical curative effect of EKC. The revised Jadad quality scoring method was used to evaluate the included literature. The chi square test was used to test the heterogeneity of the study. If the P > 0. 05 indicated the homogeneity was better,the fixed effect model was used; otherwise,the random effect model was used to calculate the combined effect. The total effective rate was expressed by relative risk( OR) and 95% confidence interval. Results 7 trials including 520 patients were included. There were 553 eyes in the treatment group and 469 eyes in the control group. 7 articles are the combination of traditional Chinese and Western medicine treatment group and the control group,the total effective rate of treating EKC,after heterogeneity test,the difference was statistically significant( I^2= 15%,P> 0. 05),suggesting good homogeneity,so we use the fixed effect model of Meta analysis. The results showed that the difference between the two groups was statistically significant( OR = 9. 00,95% confidence interval: 4.53 ~ 17.89,Z = 6.27,P<0.05). It shows that the comb
出处
《中华眼科医学杂志（电子版）》
2017年第3期114-120,共7页
Chinese Journal of Ophthalmologic Medicine(Electronic Edition)
关键词
流行性角结膜炎
中西药联合疗法
META分析
Epidemic keratoconjunctivitis
Combination of Chinese traditional and Western medicine
Meta-analysis
