摘要
目的观察卡培他滨联合奥沙利铂方案治疗进展期胃癌的疗效及TP、DPD表达的影响。方法选取2016年7月至2017年7月在本院进行治疗的进展期胃癌患者80例,采取数字表法将患者均分为对照组(采取顺铂、表阿霉素以及氟尿嘧啶联合进行治疗)、研究组(采取卡培他滨联合奥沙利铂进行治疗),对比患者的用药效果以及TP、DPD表达与其ORR两者之间存在的关系。结果研究组用药疗效明显优于对照组(P<0.05);在阳性表达中,研究组在TP的ORR明显大于对照组(P<0.05),在DPD方面的ORR显著小于对照组(P<0.05);在阴性表达中两组患者在TP、DPD方面的ORR均无显著性差异(P>0.05)。结论对进展期胃癌患者进行治疗时,采取卡培他滨联合奥沙利铂有助于TP、DPD表达,能够提高整体用药效果。
Objective To observe curative effect of capecitabine combined with oxaliplatin in treatment of advanced gastric cancer and effect of TP,DPD expression.Methods Choose 80 cases advanced gastric cancer patients treated in our hospital from July 2016 to July 2017,divide them into control group(treated with cisplatin,epirubicin and fluorouracil)and research group(treated with capecitabine and oxaliplatin)with digital table method in average.Compare medication effect and relationship between expression of TP,DPD and ORR.Results Curative effect of research group was significantly better than control group(P<0.05);in positive expression,ORR of TP in research group was significantly higher than control group(P<0.05),and ORR of DPD was significantly lower than control group(P<0.05);in negative expression,ORR of TP and DPD showed no significant difference between two groups,(P>0.05).Conclusion Capecitabine combined with oxaliplatin is helpful to expression of TP and DPD during treatment of advanced gastric cancer patients,which can improve overall medication effect.
作者
臧晔
ZANG Ye(Department of Oncology,Danyang City People's Hospital,Danyang,Jiangsu,212300)
出处
《智慧健康》
2019年第12期117-118,共2页
Smart Healthcare
