摘要
目的探讨卵巢癌患者磷酸酶及张力蛋白同源物(phosphatase and tensin homolog,PTEN)蛋白表达及其与预后的关系。方法选取2013年8月至2018年6月间西安市中医医院收治的59例卵巢癌患者及40例卵巢交界性肿瘤,分别纳入卵巢癌组与交界组。采用免疫组化法检测两组患者病理组织PTEN蛋白表达情况,同时随访调查患者的预后并进行影响因素分析。结果卵巢癌组的PTEN表达阳性率为40. 7%,显著低于交界组的90. 0%,差异有统计学意义(P <0. 05)。PTEN阳性患者的总生存时间与无进展生存时间都显著高于PTEN阴性患者,差异均有统计学意义(均P <0. 05)。PTEN表达阳性与卵巢癌组患者总生存时间和无进展生存时间呈现显著相关性,差异均有统计学意义(均P <0. 05);多因素Logistic回归方法显示,PTEN表达阴性、临床分期、分化程度和淋巴结转移为影响卵巢癌患者总生存时间的相关因素,差异均有统计学意义(均P <0. 05)。结论卵巢癌患者PTEN蛋白呈现低表达状况,PTEN蛋白较低表达患者预后较差,PTEN蛋白低是影响患者预后的重要因素。
Objective To investigate the expression of phosphatase and tensin homolog(PTEN protein in patients with ovarian cancer and its relationship with prognosis.Methods From August 2013 to June 2018,59 patients with ovarian cancer(ovarian cancer group)and 40 patients with borderline ovarian tumors(borderline group)were selected at Xi’an Hospital of Traditional Chinese Medicine.The expression of PTEN protein in pathological tissues was detected by immunohistochemistry,and all the patients were followed up to investigate the prognosis and to analyze the influencing factors.Results The positive rates of PTEN expression was 40.7%in the ovarian cancer group which was significantly lower than 90.0%of the border group(P<0.05).The overall survival time and progression-free survival time were significantly higher in patients with positive expression of PTEN than in patients with negative expression of PTEN(all P<0.05).Positive expression of PTEN was correlated with overall survival and progression-free survival(all P<0.05).Multivariate logistic regression showed negative expression of PTEN,clinical stage,differentiation,lymph node metastasis were the main factors influencing the overall survival time in patients with ovarian cancer(all P<0.05).The expression of PTEN protein was low in patients with ovarian cancer,which may lead to worse prognosis.The low expression of PTEN protein is an important factor influencing the prognosis.
作者
苗芸
刘静
申月玲
MIAO Yun;LIU Jing;SHEN Yue-ling(Department of Gynecology,Xi'an Hospital of Traditional Chinese Medicine,Xi'an710000,China;Department of Obstetrics and Gynecology,Hengshan District People's Hospital of Yulin,Yulin719100,China)
出处
《中国肿瘤临床与康复》
2019年第9期1032-1035,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
卵巢肿瘤
磷酸酶及张力蛋白同源物
预后
相关性
Ovarian neoplasms
Phosphatase and tensin homologue
Prognosis
Correlation
