摘要
黏蛋白5AC(MUC5AC)是黏蛋白家族成员之一,是胃特异性相关蛋白,是胃黏液的重要组成部分,可保护胃黏膜免受各种损伤。研究显示MUC5AC与恶性肿瘤的发生发展关系密切,可抑制胃癌的生成及进展,在胰腺癌、肺癌等肿瘤中又可促进肿瘤的发展和转移。文章将从中医"津液"及"痰饮"理论角度探讨MUC5AC在恶性肿瘤中的不同作用,以期通过中医理论来解释这一现象并探讨中医理论中"津液"及"痰饮"的现代医学内涵。
Mucin 5 AC(MUC5 AC)is a member of the mucin family and is also a gastric-specific protein.It is an important component of gastric mucus and protects the gastric mucosa from various damages.Studies have shown that MUC5 AC is closely related to the occurrence and development of malignant tumors,which can inhibit the formation and progression of gastric cancer,and promote the development and metastasis of tumors in pancreatic cancer,lung cancer and other tumors.This article discussed the different roles of MUC5 AC in malignant tumors from the perspective of"body fluid"and"phlegm and retained fluid"theory of TCM,with a view to explaining this phenomenon through TCM theory and discussing the modern medical connotation of"body fluid"and"phlegm and retained fluid"in TCM theory.
作者
李鑫
赵爱光
杨金祖
钱建新
陈舲
LI Xin;ZHAO Aiguang;YANG Jinzu;QIAN Jianxin;CHEN Ling(Department of Oncology,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Oncology,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)
出处
《辽宁中医杂志》
CAS
2020年第8期51-54,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金(81704042)
上海中医药大学预算内科研项目(2019LK003)
上海中医药大学附属龙华医院国家中医临床研究基地龙医学者(育苗计划LYTD-82)
上海中医药大学附属岳阳中西医结合医院研究项目(2019YYQ25)
关键词
津液
痰饮
黏蛋白5AC
恶性肿瘤
body fluid
phlegm and retained fluid
mucin 5AC
malignant tumors
