摘要
根治性切除是原发性肝癌的最重要治疗方式,但复发率高是影响病人术后生存的主要原因。根据复发时间,肝癌术后复发分为早期复发和晚期复发,前者主要与肿瘤侵袭转移有关,后者主要由于肝病背景基础上的多中心发生所致。早期预测术后复发风险有助于及时有效干预、改善预后。近十余年,临床上围绕肝癌术后复发进行了系统研究,对转移复发的分子机制有了新认识:肝癌转移潜能始于原发瘤早期;微环境炎性反应失衡促进癌症发生转移。同时,识别和鉴定出多种预测复发的分子标记物,创建并优化了肝癌转移分子预测模型。这些研究成果为临床更准确地把握肝癌复发转移规律,制订更加精准预防和治疗策略奠定基础。
The radical resection is the most important treatment for primary liver cancer,but the high recurrence rate is the main obstacle to the survival of postoperative patients.According to the time of tumor recurrence,the postoperative recurrence of liver cancer is divided into the early recurrence and late recurrence.The former is mainly related to the invasion and metastasis of liver cancer,and the latter is mainly caused by multicenter tumor occurrence based on the background of liver disease.The early prediction of postoperative recurrence risk contributes to the timely and effective intervention and improved the prognosis of the patients.In the past ten years,the clinical research on the recurrence of liver cancer has been systematically studied.The molecular mechanism of the metastasis and recurrence has been newly recognized:the metastatic potential of liver cancer begins in the early stage of primary tumor;the imbalance of micro-environmental inflammatory response promotes the metastasis of cancer.At the same time,a variety of molecular markers for predicting the recurrence of liver cancer were identified,and a molecular prediction model for the metastasis of liver cancer was created and optimized.These research results lay the foundation for more accurately understanding of the recurrence and metastasis of liver cancer and developing the more precise prevention and treatment strategies.
作者
杨鑫
贾户亮
钦伦秀
YANG Xin;JIA Hu-liang;QIN Lun-xiu(Department of General Surgery,Huashan Hospital,Fudan University,Shanghai 200040,China)
出处
《中国实用外科杂志》
CSCD
北大核心
2019年第10期1030-1035,共6页
Chinese Journal of Practical Surgery
基金
国家自然科学基金面上项目（No.81672365)
关键词
肝细胞癌
复发
转移
分子标记物
分子机制
hepatocellular carcinoma
recurrence
metastasis
molecular markers
molecular mechanism
