摘要
目的分析三价季节性流感裂解疫苗(SIV)在高抗体水平人群中的免疫原性。方法招募3-80岁健康人群1 200名,随机分为试验组和对照组分别接种本研究SIV和对照SIV,采集免疫前和免疫后28d血清,检测流感凝集抑制(HI)抗体,分析免疫前高抗体水平(抗体滴度≥1:10)人群免疫后抗体阳转率和几何平均滴度(GMT)增长幅度。结果试验组SIV免疫后H1N1、H3N2和B型流感HI抗体阳转率分别为78.3%(274/350)、74.1%(389/525)、69.8%(377/540);对照组分别为77.4%(254/328)、70.3%(374/532)、68.6%(376/548)。试验组免疫后与免疫前三个型别HI抗体GMT比值分别为10.4、8.8、5.9;对照组分别为9.7、6.5、5.8。结论 SIV在高抗体水平人群中具有良好的免疫原性。
Objective To determine the immunogenicity of seasonal influenza split-virus vaccine(SIV) among a highantibodylevel population. Methods We recruited 1 200 healthy individuals aged 3-80 years, and randomly allocated them into a study group and a control group who were vaccinated with the study SIV and a control SIV, respectively.We collected serum samples before and 28 days after vaccination to assess influenza HI antibody levels. We analyzed seroconversion rates and changes in geometric mean titers(GMT) of HI antibody after vaccination among subjects who had a high antibody level(antibody titer ≥1:10) before vaccination. Results Seroconversion rates of H1 N1, H3 N2 and B influenza HI antibodies were 78.3%(274/350), 74.1%(389/525), and 69.8%(377/540) in the study SIV group,respectively, and were 77.4%(254/328), 70.3%(374/532), and 68.6%(376/548) in the control SIV group. GMT ratios of three types of influenza HI antibodies af ter and before vaccination were 10.4, 8.8, and 5.9 in the study group,respectively, and were 9.7, 6.5, and 5.8 in the control group. Conclusion The study SIV had good immunogenicity among people with high antibody levels.
作者
高菁霞
赵玉良
刘金凤
刘淑珍
廖国阳
陈洪波
Gao Jingxia;Zhao Yuliang;Liu Jinfeng;Liu Shuzhen;Liao Guoyang;Chen Hongbo(Institute of Medical Biology,Chinese Academy of Medical Science and Peking Union Medical College,Kunming 650118,Yunnan,China;Hebei Provincial Center for Disease Control and Prevention,Shijiazhuang 050000,Hebei,China;Dingxing County Center for Disease Control and Prevention,Dingxing 072650,Hebei,China;National Institute for Food and Drug Control,Beijing 100050,China)
出处
《中国疫苗和免疫》
北大核心
2019年第1期68-71,共4页
Chinese Journal of Vaccines and Immunization
基金
医学院创新工程四价流感病毒裂解疫苗(2016-I2M-1-019)
医学院协同创新团队项目(2016-I2M-3-026)
云南省科技创新人才计划项目-疫苗研发与新技术应用研究省创新团队项目(2015HC027)
关键词
季节性流感裂解疫苗
免疫原性
Seasonal influenza split vaccine
Immunogenicity
