摘要
目的了解北京市某区1起流行性腮腺炎(流腮)暴发的腮腺炎病毒(MuV)基因特征。方法对该起暴发中的疑似流腮病例采集咽拭子标本,开展MuV核酸检测和病毒分离,进行SH基因分型、亲缘关系和变异分析。结果本起疫情共分离出8株MuV毒株,其SH核苷酸序列完全相同,均为F基因型。所有分离株与北京市历年MuV毒株之间核苷酸序列差异为1-17个(0.3%-5.4%),属于同一个分支。结论北京市优势MuV毒株仍为F基因型,但型内差异较大,需加强流腮的持续性病毒学监测。
Objective To analyze genetic characteristics of mumps virus from a mumps outbreak in a district in Beijing.Methods We collected throat swabs from suspected mumps cases during the outbreak to test for mumps virus nucleic acid and to isolate virus. We determined SH-gene-based genotypes, genetic homology, and genetic variations. Results Eight strains of mumps virus were isolated f rom the outbreak;all were F genotype. There were 1-17(0.3%-5.4%)nucleic acid differences between theses isolates and strains isolated in previous years in Beijing, indicating that they belonged to the same phylogenetic branch. Conclusions F genotype was the predominant mumps genotype circulating in Beijing. There was a high variation within the F genotype across the years. We should strengthen continuous mumps virus monitoring.
作者
舒高林
吴杨
张阳
赵炳岩
庄鹏
高进玺
陈萌
Shu Gaolin;Wu Yang;Zhang Yang;Zhao Bingyan;Zhuang Peng;Gao Jinxi;Chen Meng(Changping District Center for Disease Control and Prevention,Bei jing 102200,China;Beijing Municipal Center for Disease Control and Prevention,Beijing 100013,China)
出处
《中国疫苗和免疫》
北大核心
2019年第1期28-32,共5页
Chinese Journal of Vaccines and Immunization
基金
北京市自然科学基金(7172105)
