摘要
目的调查南京及其周边地区孕妇人群戊型肝炎病毒(hepatitis E virus,HEV)感染状况。方法912例中孕期孕妇血清采用ELISA法初筛血清抗-HEV IgG和IgM抗体,初筛阳性血清进一步采用Western Blot确认。结果南京及其周边地区中孕期孕妇人群抗-HEV IgG抗体阳性率为13.6%(124/912),抗-HEV IgM抗体阳性率为1.4%(13/912)。在【21岁、21~25岁、26~30岁和】30岁孕妇中,抗-HEV IgG阳性率分别为14.0%(6/43)、12.6%(62/492)、15.2%(39/256)、12.1%(17/121);抗-HEV IgM阳性率分别为2.3%(1/43)、1.0%(5/492)、1.2%(3/256)和3.3%(4/121);各年龄组抗-HEV IgG和IgM抗体阳性率差异均无统计学意义(P】0.05)。所有抗-HEV IgM阳性血清,同时抗-HEV IgG阳性。结论南京及其周边地区中孕孕妇人群存在HEV散发感染,以无症状的隐性感染为主。
Objective To investigate the seroprevalence of hepatitis E virus (HEV) infection in pregnant women in Nanjing and the surrounding areas .Method The sera collected from 912 pregnant women at gestation age of 15‐21 weeks were tested for anti‐HEV IgG and IgM with ELISA and then confirmed by Western Blot .Results The overall prevalence of anti‐HEV IgG and anti‐HEV IgM in pregnant women were 13 .6% (124/912) and 1 .4% (13/912) ,respectively .The positive rates of anti‐HEV IgG in the pregnant women at the ages of <21 ,21~25 ,26~30 ,and >30 years were 14 .0% (6/43) ,12 .6% (62/492) ,15 .2% (39/256) and 3 .3% (17/121) ,respectively ,and the positive rates of anti‐HEV IgM in those four groups were 2 .3% (1/43) ,1 .0% (5/492) ,1 .2% (3/256) ,and 1 .2% (4/121) ,respectively ;the prevalence of anti‐HEV IgG and IgM did not differ significantly among the four age groups ( P>0 .05) .All the anti‐HEV IgM positive samples were also IgG positive .Conclusions Sporadic cases of HEV infection in pregnant women were detected in Nanjing and the surrounding areas ,mainly with sub‐clinical infections .
出处
《中国产前诊断杂志（电子版）》
2015年第1期26-30,共5页
Chinese Journal of Prenatal Diagnosis(Electronic Version)
基金
国家临床重点专科建设项目(2011271)
江苏省科技发展计划项目(BL2012015)
江苏省母胎医学重点学科建设项目(XK201102)
南京市卫生人才工程项目(QRX11024)
关键词
戊型肝炎病毒
孕妇
血清学调查
hepatitis E virus
pregnant women
seroprevalence
