摘要
目的 研究nm2 3基因在膀胱癌中的表达及临床意义。方法 对 47例膀胱癌标本进行S -P免疫组化染色 ,分析nm2 3蛋白表达与膀胱癌关系。结果 nm2 3蛋白在膀胱癌组织及非癌粘膜中均有表达 ,定位于细胞浆。 72 .3 4%的膀胱癌组织nm2 3蛋白染色阳性 ,阳性率明显高于非癌粘膜 (P <0 .0 5 )。nm2 3蛋白高度表达与膀胱癌细胞的低度分化及局部浸润有关 ,与肿瘤大小无关。结论 在膀胱癌中nm2 3基因可促进膀胱癌的发生和发展 ,nm2 3蛋白对于判断膀胱癌细胞的恶性程度 ,肿瘤进展以及预后有重要价值。
Objectives To investigate the expression of nm23 protein in bladder carcinoma and evaluate it's clinical significance. Methods We studied the expression of nm23 protein in 47 cases of bladder carcinoma by the method of SP immunohistochemistry. The relationship between nm23 protein expression and bladder carcinoma were analyzed. Results The expression of nm23 protein was detected in both bladder carcinoma tissue and non-carcinoma mucosa, and the nm23 protein was located in cytoplasm. Positive rate of nm23 protein in bladder carcinoma was 72.34%; it was higher than that of non-carcinoma tissue (P<0.05). The high expression rate of nm23 protein was associated with poor differentiations and local infiltration, but it was not associated with tumor size. Conclusions The nm23 gene in bladder carcinoma could not be a metastasis suppressor gene; on the contrary, it could promote the genesis and progression of bladder carcinoma; examination of nm23 protein might be of some value to judge the malignancy, development and prognosis.
出处
《实用全科医学》
2004年第1期22-23,共2页
Applied Journal Of General Practice
关键词
膀胱癌
NM23蛋白
癌细胞
基因
nm23 protein
Immunohistochemistry
Bladder carcinoma
