摘要
目的 :采用四唑盐 (MTT)药敏试验方法筛选对肺癌的敏感药物并指导临床化疗 .方法 :将 1 4 5例 4种不同类型的肺癌 ,分为MTT试验组和未接受MTT对照组 .接受MTT药敏试验者 ,根据药敏结果指导化疗 ,未接受MTT药敏对照组凭经验化疗 .结果 :体外药敏试验与临床治疗结果的总符合率为 89.3% ;阳性符合率为 90 .9% ;阴性符合率为77.8% ;试验敏感性为 96 .8% ;特异性为 5 3.8% .接受MTT药敏试验者临床治疗有效率明显高于凭经验化疗对照组 .结论 :MTT体外药敏试验与临床治疗敏感性有很好的相关性 。
AIM: To screen sensitive drugs to lung cancer for clinical chemotherapy by using MTT drug sensitive test. METHODS: 145 cases of four different kinds of lung cancers were divided into two groups: the MTT test group and the control group. The MTT group were treated according to the drug sensitive result, while the control group were treated by sheer experience. RESULTS: The matching ratio of the drug sensitive test result and curative effects was 89.3%, with the positive matching ratio being 90.9%, while the negative ratio 77.8%. The sensitivity of test was 96.8% and the specificity was 53.8%. The curative effects of clinical therapy in the MTT test group were better than those in the control group. CONCLUSION: There is a good correlation between MTT drug sensitive test in vitro and the curative effects of clinical therapy, indicating it is a viable method in screening drugs for clinical chemotherapy.
出处
《第四军医大学学报》
北大核心
2003年第23期2203-2205,共3页
Journal of the Fourth Military Medical University
关键词
肺肿瘤
药敏试验
四唑盐法
lung neoplasms
drug sensitive test
MTT method
