摘要
目的 探讨慢性肾脏疾病患者外周血T淋巴细胞亚群的变化。方法 6 6例慢性肾脏疾病患者测定外周血T淋巴细胞亚群 (CD4、CD8、CD4 /CD8)、血清总蛋白 (TP)、血清白蛋白 (A1)、血清尿素氮 (BUN)、血清肌酐 (Scr)、血清甘油三酯 (TG)、血清胆固醇 (CHO)和 2 4h尿蛋白定量 (Pr/ 2 4h)。结果 :慢性肾脏疾病组CD4 (P <0 .0 5 )、CD4 /CD8、TP、A1(P <0 .0 0 1)均低于正常对照组 ,而CD8、BUN、Scr(P <0 .0 5 )、Pr/ 2 4h(P <0 .0 1)均高于正常对照组。CD8与Scr呈明显负相关 (P <0 .0 1)。而CD4、CD4 /CD8与Scr无明显相关性 (P>0 .0 5 ) ,CD4、CD8、CD4 /CD8与Pr/ 2 4h、TP、A1、BUN、TG、CHO无明显相关性 (P >0 .0 5 )。结论 慢性肾脏疾病患者存在T细胞功能紊乱 ,其与肾功能呈负相关 ,但与肾脏病患者尿蛋白排泄无明显相关性。
Objective:To investigate the changes in T lymphocyte subsets of peripheral blood in patients with chronic renal diseases.Methods:In 66 patients with chronic renal diseases, biotin-streptavidin-peroxidase was used to T lymphocyte subsets(CD4,CD8,CD4/CD8),and the levels of serum blood total protein (TP),albumin(A1), urea nitrogen(BUN),creatinine (Scr), triglyceride (TG),Cholesterol(CHO),total urine protein per 24 hours(Pr/24 h), et al.were assayed and then analyzed with statistics.Results:The levels of CD4(P<0.05),CD4/CD8,TP and Al(P<0.01) in chronic renal disease group were all lower than those of the normal compared group, the levels of CD8,BUN, Scr(P<0.05) and Pr/24 h(P<0.01) were all higher than those of normal subjects. In the chronic renal disease group, Scr was negatively correlated with CD8(P<0.01), and not significantly correlated with CD4 and CD4/CD8(P> 0.05),there was no significant correlation between CD4,CD8,CD4/CD8 and Pr/24 h,TP,Al,BUN,TG CHO(P> 0.05).Conclusions:Immune disorder is present in the peripheral blood of chronic renal disease patients,which is negatively correlated with renal functions but not significantly correlated with the excretion of urine protein.
出处
《中国现代医学杂志》
CAS
CSCD
2004年第1期47-49,共3页
China Journal of Modern Medicine
