摘要
目的:研究环氧化酶-2(COX-2)基因在肺癌中的表达及其与临床病理特征之间的关系。方法:RT-PCR检测56例肺癌组织及相对应的癌旁正常组织、12例肺良性病变组织的COX-2mRNA表达。结果:肺癌组织COX-2基因表达阳性率(60.7%)高于相应癌旁正常组织(10.7%)和肺良性病变(25.0%)(P<0.01;P<0.05),腺癌高于鳞癌(P<0.01),但与患者的年龄、性别、TNM分期及肿瘤组织的分化程度无明显相关(P>0.05)。结论:COX-2基因在肺癌组织尤其是肺腺癌中表达上调,提示该基因对肺癌的发生、发展起重要作用,COX-2基因有望成为肺癌基因治疗的靶位点。
Objective:To study the expression of cyclooxygenase2(COX-2)gene and its relationship with clinical pathalogocal characteristics in lung cancer.Methods:Expression of the COX-2mRNA was evaluate by RT-PCR in cancerous tissues and adjacent noncancerous tissues from56patients and benign lesions from12patients.Results:Expression of COX-2gene was detected in a significantly greater proportion of cancerous tissues(60.7%)than adjacent noncancer-ous tissues(10.7%)and benign lesions(3/12),and was higher in adenocarcinoma than in squa-mous carcinoma (P<0.01).There was no significient relationship between COX-2gene expression and patients age,sex,TNM stages and tumor histologic differentiation(P>0.05).Conclusion:The up-regulation of COX-2gene in lung cancer tissues expecially in adenocarcinoma suggested that COX-2may play a role in the pathway of lung carcinogenesis and COX-2gene may be identi-fied as a potential therapeutic target in lung cancer.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2003年第10期728-730,共3页
Chinese Journal of Clinical Oncology
关键词
肺癌
环氧化酶-2
基因
Lung cancer Cyclooxygenase 2 Gene
