摘要
目的探讨步行—执行功能双任务训练对缺血性卒中后遗症期患者肝细胞生长因子(HGF)表达、血清趋化素样因子-1 (CKLF1)及巨噬细胞移动抑制因子(MIF)的影响,为提高临床治疗效果提供参考。方法选取广东省惠州市中心人民医院2017年8月—2018年7月收治的40例缺血性卒中患者作为研究对象,随机分为研究组和对照组,每组20例。所有患者均接受常规治疗,对照组接受常规康复干预,观察组在对照组基础上接受步行—执行功能双任务训练干预,两组均干预2个月。干预前后,采用双抗体夹心酶联免疫吸附法测定并比较两组患者血清HGF、CKLF1及MIF水平;采用生存质量指数量表(QLI)评估并比较两组生存质量;采用汉密尔顿抑郁量表(HAMD)评估并比较两组抑郁程度。结果干预前,两组血清HGF、CKLF1及MIF水平比较,差异无统计学意义(P>0.05);干预后,两组HGF、CKLF1及MIF水平均低于本组干预前,且两组比较,差异有统计学意义(P<0.05)。干预前,两组各项生存质量评分比较,差异无统计学意义(P>0.05);干预后,研究组活动能力、健康感受、家庭支持和生活前景等各项生存质量评分均高于本组治疗前和同期对照组,差异有统计学意义(P<0.05)。干预前,研究组HAMD评分为(22.18±1.83)分,与对照组的(21.88±1.66)分比较,差异无统计学意义(P>0.05)。干预后,研究组HAMD评分为(10.02±1.34)分,明显低于对照组的(18.43±1.73)分,差异有统计学意义(P<0.05)。结论步行—执行功能双任务训练有助于降低缺血性卒中后遗症期患者血清HGF、CKLF1及MIF水平,并有助于改善患者生存质量,降低患者抑郁程度。
Objective To investigate the influence of sequelae in walking-execution function on the expression of hepatocyte growth factor(HGF), serum chemokine-like factor-1(CKLF1) and macrophage migration inhibitory factor(MIF) in patients with ischemic stroke. Methods Forty patients with ischemic stroke sequelae were enrolled from Guangdong Huizhou Central People’s Hospital from August 2017 to July 2018. They were randomly divided into observation group and control group,with 20 cases in each group. All patients received routine treatment, the control group received routine rehabilitation intervention, and the observation group received walking-exercise dual-task training intervention on the basis of the routine rehabilitation intervention. Subjects were treated for 2 months. Before and after the intervention, serum HGF, CKLF1 and MIF levels were measured by double antibody sandwich enzyme-linked immunosorbent assay, and evaluated by QLI. Results Before intervention, the levels of serum HGF, CKLF1 and MIF in the two groups were not significantly different(all P>0.05). After intervention, the levels of HGF, CKLF1 and MIF in the observation group were lower than those in the control group(all P<0.05). QLI scores in the two groups were not significantly different(all P>0.05) before intervention, but QLI scores such as activity capacity, health feeling, family support and life prospects in observation group were significantly higher than those in control group after intervention(all P<0.05). Before intervention, the HAMD score in observation group and control group were(22.18±1.83) scores,(21.88±1.66) scores, respectively, and there was not significantly different(P>0.05). After intervention, the HAMD scores in observation group were lower than those in control group ((10.02 ± 1.34) scores vs.(18.43 ± 1.73) scores)Conclusion The walking-execution function dual-task training can help to reduce serum HGF, CKLF1 and MIF levels and improve life equality and reduce the degree of depression in patients with sequelae of ischem
作者
黄步哲
黄燕芳
方玮
HUANG Bu-zhe;HUANG Yan-fang;FANG Wei(Guangdong Huizhou Central People's Hospital,Huizhou,Guangdong 516000,China)
出处
《慢性病学杂志》
2019年第2期188-191,共4页
Chronic Pathematology Journal
