摘要
目的考察甘露醇注射液与地塞米松注射液配伍应用的安全性与稳定性,为药物临床配伍合理使用提供参考。方法采用高效液相色谱(HPLC)法测定不同温度、不同剂量的地塞米松加入条件下甘露醇饱和溶液的含量,采用激光-微粒分析仪测定加入地塞米松对甘露醇不溶性微粒的影响。结果随着温度降低,甘露醇溶解度明显下降;地塞米松能降低甘露醇的溶解度,其降低程度与地塞米松加入量呈正相关。结论加入地塞米松的甘露醇注射液在较低温度下易析出结晶;地塞米松与甘露醇注射剂最好分开使用或现配现用,且确保其液体温度超过20℃;复方甘露醇注射液可替代甘露醇注射液与地塞米松配伍使用,更安全稳定。
Objective To study the compatibility and stability of mannitol and dexamethasone injection,and to provide reference for rational drug use. Methods Different concentrations and particles of mannitol injection with or without dexamethasone were determined by HPLC and injection microparticle analyzer. Results Solubility of mannitol positively correlated with temperature. The solubility of mannitol reducing was associated with dexamethasone. Conclusion The mannitol injection is easily precipitate crystalline with temperature decreases or adding dexamethasone. Mannitol and dexamethasone injection are better to be used separately,or make them up and use it immediately and ensure its liquid temperature above 20 ℃. Compound mannitol and dexamethasone injection is compatible.
出处
《中国药业》
CAS
2015年第22期43-45,共3页
China Pharmaceuticals
关键词
甘露醇
地塞米松
配伍
稳定性
mannitol
dexamethasone
compatibility
stability
