摘要
目的探讨血清人软骨糖蛋白-39（YKL-40）与妊娠期糖尿病（GDM）的相关性。方法选取2015年2月2016年2月浙江省瑞安市人民医院收治的GDM患者50例作为试验组,选取50例年龄相仿的正常健康妊娠孕妇作为正常对照组。治疗前后观察两组受试者血清YKL-40、空腹血糖（FPG）、糖化血红蛋白(Hb A1c)、空腹胰岛素（FINS）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、身高、体重、血压、体重指数（BMI）以及胰岛素抵抗指数（HOMA-IR）。结果试验组妊娠妇女FPG、FINS、HOMA-IR以及血清YKL-40水平均高于正常对照组,差异均有统计学意义（P<0.05或P<0.01）。相关性分析结果显示,血清YKL-40水平与孕期BMI值、Hb A1c、FINS以及HOMA-IR均呈正相关（r=0.482、0.603、0.201、0.317,P<0.05或P<0.01）。多元线性逐步回归分析结果显示,Hb A1c（β=0.337,P<0.01）、FINS（β=0.348,P<0.01）及HOMA-IR（β=0.138,P<0.05）是血清YKL-40水平的独立影响因素。结论 GDM患者血清YKL-40水平明显升高,且YKL-40水平与Hb A1c、FINS以及HOMA-IR相关,提示YKL-40可能参与了GDM的发生、发展。
Objective To explore the correlation of serum human cartilage glycoprotein-39(YKL-40) with gestational diabetes mellitus(GDM). Methods From February 2015 to February 2016, fifty patients with GDM in Rui'an People's Hospital were regarded as the experimental group, fifty age-matched healthy pregnant women were regarded as the control group. Before and after treatment, YKL-40, fasting plasma glucose(FPG), Hb A_(1c), fasting insulin(FINS), totalcholesterol(TC), triglycerides(TG), high-density-lipoprotein cholesterol(HDL-C), low-density-lipoprotein cholesterol(LDL-C), body mass index(BMI) and HOMA-IR were observed. Results Levels of serum FPG, FINS, HOMA-IR, and YKL-40 were significantly higher in experimental group compared with those of the control group, the differences were statistically significant(P < 0.05 or P < 0.01). Correlation analysis showed that, level of serum YKL-40 was positively correlated with current BMI, Hb A_(1c), FINS and HOMA-IR(r = 0.482, 0.603, 0.201, 0.317, P < 0.05 or P < 0.01). Linear multiple regression analysis showed that, Hb A1c(β = 0.337, P < 0.01), FINS(β = 0.348, P < 0.01) and HOMA-IR(β =0.138, P < 0.05) were the independent determinants of serum YKL-40. Conclusion Level of serum YKL-40 is elevated in patients with GDM, and the level of YKL-40 is related to Hb A_(1c), FINS and HOMA-IR. These results suggested that YKL-40 may be a major contributor to GDM.
出处
《中国医药导报》
CAS
2016年第29期75-78,共4页
China Medical Herald
