摘要
目的观察高龄重症肺炎患者血清中过氧化物及抗氧化物水平的情况及其与患者病情严重程度及预后的关系。方法选取我院重症监护室重症肺炎患者60例为观察组,另选取呼吸内科40例非重症肺炎患者为对照组。检测两组患者入院时血清丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)水平,方差分析比较两组患者的差异。另在观察组中将7天观察时限内死亡的患者作为死亡组,7天内存活的患者为存活组,检测患者入ICU 2 h及第3、5、7天的血清过氧化水平,同时评价急性生理学与慢性健康状况评分Ⅱ(APACHE Ⅱ)评分,方差分析比较两组患者MDA、SOD及APACHE-Ⅱ评分的差异,并对患者APACHE-Ⅱ评分与MDA、SOD水平进行Spearman相关性分析。结果观察组患者血清MDA显著高于对照组,差异有统计学意义(P<0.05),观察组患者血清SOD活性显著低于对照组,差异有统计学意义(P<0.05)。观察组中,死亡组MDA含量在第5、7天时显著高于存活组,差异有统计学意义(P<0.05)。死亡组SOD水平在第7天时显著低于存活组,差异有统计学意义(P<0.05)。死亡组APACHE-Ⅱ评分在第5、7天时显著高于存活组,差异有统计学意义(P<0.05)。Spearman相关性分析结果示:观察组患者MDA水平与APACHE-Ⅱ评分正相关(r_s=0.815,P<0.05),SOD水平与APACHE-Ⅱ评分负相关(r_s=-0.762,P<0.05)。结论重症肺炎患者血清中过氧化水平显著高于非重症肺炎患者,且患者血清过氧化水平越高患者病情越严重,预后越差,提示重症肺炎中血清过氧化水平能良好地反映病情及预后,对临床工作有良好的指导作用。
Objective To observe the levels of serum superoxide and antioxidants in elderly patients with severe pneumonia and their relationship with the severity of the disease and the prognosis.Methods 60 cases of severe pneumonia in our hospital were selected as the observation group, and 40 cases of non severe pneumonia were selected as the control group. The levels of serum malondialdehyde(MDA),superoxide dismutase(SOD) were detected in the two groups of patients and the differences between the two groups were compared. In the observation group(patients with severe pneumonia), patients who died within 7days of observation were treated as death group. Survival group was survived within 7 days. Serum levels of peroxidation were measured in ICU at 2 h and 3, 5, 7 days respectively. The APACHE-Ⅱ score was evalated.The differences of MDA, SOD and APACHE-Ⅱ scores were compared between the death and survival groups.Spearman correlation analysis was performed on the APACHE-Ⅱ score and MDA or SOD levels. Results The serum MDA of the observation group was significantly higher than that of the control group, the difference was statistically significant(P<0.05). The serum SOD activity of the observation group was significantly lower than that of the control group, the difference was also statistically significant(P<0.05). In the observation group, the content of MDA in the death group was significantly higher than that in the survival group at five and seven days, and the difference was statistically significant(P<0.05). The SOD level in survival group was significantly higher than that in the death group at seven day, and the difference was statistically significant(P<0.05). The death group APACHE-Ⅱ score was significantly higher than that in the survival group at five and seven days, and the difference was statistically significant(P<0.05). Spearman correlation analysis showed that the levels of MDA in patients with APACHE-Ⅱ score and observed positive correlation(r_s= 0.815, P<0.05),the level of SOD negative correlati
出处
《分子诊断与治疗杂志》
2017年第3期191-195,共5页
Journal of Molecular Diagnostics and Therapy
