摘要
目的:探讨伴攻击行为酒精依赖者认知功能特点及P300潜伏期和波幅特征。方法:采用认知功能量表(RBANS量表)和事件相关电位仪(日本光电MEB9200K)对伴或不伴攻击行为的酒精依赖患者各40例和40例健康对照进行对照研究,比较各组在认知功能各维度、P300潜伏期及波幅变化的差异性。结果:RBANS的结果表明,与不伴攻击行为组相比,伴攻击行为酒精依赖组在即时记忆及注意功能方面损害更为明显(P <0. 01)。P300研究结果显示:与正常对照相比,伴或不伴攻击行为酒依赖组的P300潜伏期延长,波幅下降,差异具有显著性(P <0. 01或P <0. 05)。与不伴攻击行为组相比,伴攻击行为酒精依赖组的P200波幅和P300波幅明显降低(P <0. 01)。结论:伴攻击行为酒精依赖者较不伴攻击行为酒精依赖者在即时记忆、注意功能方面损害更明显,且P300波幅下降更大,提示伴攻击行为酒精依赖者认知功能障碍更为严重。
Objective:To investigate the characteristics of P300 latency and amplitude and cognitive function in alcohol dependent patients with aggressive behavior.Methods:A case-control study was performed using an event-related potential analyzer(MEB9200 K,Japan Optoelectronics Corporation)and an RBANS scale for 40 patients with alcohol dependence with or without aggressive behavior and 40 healthy controls.The latency and amplitude of P300 in each group were compared.Results:Compared with the normal control group,the latency of P300 in alcohol dependence group with or without aggressive behavior was prolonged and the amplitude was decreased.The difference was significant.There was no significant difference in the latency of P300 in alcohol dependence group with aggressive behavior compared with the group without aggressiveness,but the amplitude decreased more significantly.The results of RBANS showed that compared with the group without aggressive behavior,the alcohol dependence group with aggressive behavior was Impairments in immediate memory and its attentional functions are more pronounced.Conclusion:The P300 amplitude of alcoholic dependent persons with aggressive behaviors is lower than that of alcoholic dependent individuals without aggressive behaviors.The impairment of immediate memory and attentional function is significant,suggesting that cognitive function impairment is more serious.
作者
徐佳兵
杨岭
周旭辉
XU Jiabing;YANG Ling;ZHOU Xuhui(Hunan Brain Hospital,Clinical Medical College of Hunan University of Traditional Chinese Medicine,Changsha,410007)
出处
《中国药物依赖性杂志》
CAS
CSCD
2018年第6期416-420,共5页
Chinese Journal of Drug Dependence
基金
湖南省自然科学青年基金(2015JJ3095)
湖南省卫生计生委科研计划课题(C2015-44)
湖南省中医药管理局重点科研项目(201431)
湖南省卫生厅计划项目(B2013-086)
湖南省中医药科研计划项目(201278)
湖南省脑科医院成瘾重点专科专项基金
湖南中医药大学教改课题"中医院校中西医结合精神病学课程的探索与实践"(JG2015B072)资助
关键词
酒精依赖
攻击行为
认知功能
事件相关电位
alcohol dependence
aggressive behavior
cognitive function
event-related potential
