摘要
目的 观察富马酸喹硫平联合重复经颅磁刺激治疗男性酒精依赖的效果。方法 纳入2021年3月至2022年9月内蒙古自治区精神卫生中心精神科收治的118例男性酒精依赖患者,以随机数字表法分成观察组(59例)和对照组(59例),给予对照组患者富马酸喹硫平治疗,给予观察组富马酸喹硫平联合重复经颅磁刺激治疗,比较两组治疗前后宾夕法尼亚酒精渴求量表(PACS)、酒精依赖调查测试问卷(MAST)评分变化,焦虑自评量表(SAS)与抑郁自评量表(SDS)评分变化,不良反应发生情况,及治疗后6、12个月疾病复发率。结果 观察组患者治疗后PACS评分,MAST评分,SAS评分,SDS评分[分别为(9.16±1.02)分,(8.78±1.00)分,(33.27±4.99)分,(31.26±5.82)分]均低于对照组[分别为(12.24±2.00)分,(13.00±1.37)分,(44.34±5.17)分,(40.76±7.72)分],t=10.538,19.111,11.834,7.548,均P<0.05;观察组(3.39%)与对照组(1.69%)不良反应发生率相当,观察组(0)与对照组(3.39%)治疗后6个月复发率相当,差异均无统计学意义(χ^(2)=0.342,2.035,均P>0.05);观察组治疗后12个月复发率为3.39%,低于对照组的13.56%,差异有统计学意义(χ^(2)=3.933,P<0.05)。结论 富马酸喹硫平联合重复经颅磁刺激治疗男性酒精依赖效果显著,可减轻患者的酒精依赖情况,改善负性情绪,安全可靠。
Objective To investigate the efficacy of quetiapine fumarate combined with repeated transcranial magnetic stimulation in treatment of male alcohol dependence.Methods A total of 118 male alcohol-dependent patients admitted to Mental Health Centre of Inner Mongolia Autonomous Region from March 2021 to September 2022 were divided into the observation group(n=59)and the control group(n=59)by random number table method.The patients in the control group were treated with quetiapine fumarate tablets while those in the observation group with quetiapine fumarate tablets combined with repeated TMS.The changes in Pennsylvania Alcohol Craving Scale(PACS)and Alcohol Dependence Questionnaire(MAST),the changes in Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)scores,the occurrence of adverse reactions,and the recurrence rate of the disease at the 6th and 12th month after treatment were compared between the two groups.Results In the observation group,PACS score was(9.16±1.02)points,MAST score was(8.78±1.00)points,SAS score was(33.27±4.99)points and SDS score was(31.26±5.82)points after treatment,which were lower than those of the control group((12.24±2.00)points,(13.00±1.37)points,(44.34±5.17)points and(40.76±7.72)points,t=10.538,19.111,11.834,7.548,all P<0.05).The adverse reaction rate of the observation group(3.39%)was similar to that of the control group(1.69%),and the recurrence rate of the observation group(0%)was also similar to that of the control group(3.39%)at the 6th month after treatment,showing no statistical significance(x^(2)=0.342,2.035,both P>0.05).The recurrence rate of the observation group was 3.39%after 12 months of treatment,which was significantly lower than that of 13.56%in the control group(x^(2)=3.933,P<0.05).Conclusion Quetiapine fumarate combined with repetitive transcranial magnetic stimulation has a significant effect in the treatment of male alcohol dependence because it can reduce the alcohol dependence of patients and improve negative mood.Meanwhile,this regimen is safe
作者
孙晶晶
敖登格日勒
Sun Jing-jing;Aodenggerile(Department of Psychiatry,Mental Health Centre of Inner Mongolia Autonomous Region,Hohhot 010010,China)
出处
《中国药物应用与监测》
CAS
2024年第4期412-415,共4页
Chinese Journal of Drug Application and Monitoring
关键词
酒精依赖
重复经颅磁刺激
富马酸喹硫平
不良反应
复发
Alcohol dependence
Repeated transcranial magnetic stimulation
Quetiapine fumarate
Adverse reaction
Recurrence
