摘要
目的观察注射用丹参多酚酸联合疏血通治疗脑梗死的临床疗效。方法将68例急性脑梗死患者随机分为两组,各34例。对照组用疏血通6 mL加0.9%氯化钠250 mL,静脉滴注,1次/d;观察组在对照组基础上加用注射用丹参多酚酸0.13 g加0.9%氯化钠250 mL,静脉滴注,1次/d,两组均治疗14 d,比较两组的临床有效率以及血液流变学指标。结果治疗后,观察组临床总有效率79.41%,高于对照组的55.88%,观察组的临床疗效优于对照组的(P<0.05);两组血液黏度、血浆黏度和血浆纤维蛋白原较治疗前均有改善(P<0.05),且观察组改善程度较对照组更为显著(P<0.05)。结论注射用丹参多酚酸联合疏血通治疗脑梗死能有效控制病情发展,疗效显著,值得临床推广。
Objective To observe the effect of Salvianolic Acids for Injection(SAFI) combined with Shuxuetong Injection in treatment of cerebral infarction. Methods A total of 68 patients with cerebral infarction were randomly divided into observation group(n = 34) and control group(n = 34). The control group were treated with Shuxuetong Injection 6 mL added into 0.9% normal saline 250 mL, intravenous drip once daily. The observation group were treated with Shuxuetong Injection combined with SAFI 0.13 g added for 0.9% sodium chloride 250 mL, intravenous drip once daily. All patients in the two groups were treated for 14 d, and the clinical effective rate and hemorheological indexesof two groups were compared. Results After treatment, the total effective rate of the observation group 79.41% was significantly higher than that of the control group 55.88%(P < 0.05). The clinical effect of the observation group was better than that of the control group(P < 0.05). The blood viscosity, plasma viscosity, and plasma fibrinogen(FIB) of the observation group were significantly lower than those of the control group(P < 0.05). Conclusion Salvianolic Acids for Injection combined with Shuxuetong Injection have significant clinical effect on the progression of cerebral infarction, and the curative effect is remarkable and worthy of clinical promotion.
作者
关翠英
颜世超
GUAN Cuiying;YAN Shichao(Yichun Hospital of Traditional Chinese Medicine in HeiLongjiang Province,Yichun 153000,China)
出处
《药物评价研究》
CAS
2019年第2期324-326,共3页
Drug Evaluation Research
关键词
脑梗死
注射用丹参多酚酸
疏血通注射液
纤维蛋白原
cerebral infarction
Salvianolic Acids for Injection(SAFI)
Shuxuetong Injection
fibrinogen
