摘要
目的 :研究碱性成纤维细胞生长因子 (b FGF)在非小细胞肺癌 (NSCLC)中的表达及其生物学意义 ,并探讨其与肿瘤血管形成和淋巴结转移的关系。 方法 :用免疫组化染色技术对 95例NSCLC石蜡组织标本的b FGF及肿瘤内微血管密度 (IMVD)进行检测和分析。 结果 :b FGF在肿瘤细胞阳性表达率明显高于癌旁的正常肺组织 (P <0 .0 5 )。b FGF阳性表达癌组织中的IMVD高于阴性表达癌组织中的IMVD(P <0 .0 5 )。b FGF表达与TNM分期和淋巴结转移有关 (P <0 .0 5 ) ,与组织学分型和肿瘤病理分级无关 (P >0 .0 5 )。 结论 :b FGF可能参与NSCLC的新血管生成并促进肿瘤转移 ;b
Objectives:To investigate the expression and distribution of b FGF in human non small cell lung cancer (NSCLC),and to evaluate the relationship between the expression of b FGF and the biological behavior of NSCLC, especially tumor angiogenesis and lymph node metastasis. Methods:The expression of b FGF and IMVD in 95 patients with NSCLC was examined using immunohistochemical methods (SP), and the relationship between the expression and many clinicopathological parameters were analyzed. Results: The positive rates of b FGF in carcinoma tissue (NSCLC) were much higher than those in the normal lung tissues nearby ( P <0.05). The positive expression of b FGF was associated with IMVD , lymph node metastases , and TNM stage of NSCLC( P <0.05),and the expression was not related to the histological subtype and pathological grade ( P >0.05). Conclusions: b FGF may play an important role in tumor angiogenesis and lymphatic metastasis of human NSCLC , and detection of b FGF may be a good metastasis and prognostic predictors for human NSCLC.
出处
《医学研究生学报》
CAS
2003年第4期248-250,共3页
Journal of Medical Postgraduates
基金
南京军区南京总医院科研基金资助项目 (批准号 :2 0 0 2 0 3 8)
关键词
碱性成纤维细胞生长因子
免疫组化
非小细胞肺癌
血管形成
淋巴结转移
Basic fibroblast growth factor
Immunohistochemistry
Non small cell lung cancer
Angiogenesis
Lymph node metastasis
