摘要
成纤维细胞生长因子 (FGFs)家族已发现有 2 1个成员 ,其中哺乳动物有 9个。成纤维细胞生长因子受体 (FGFRs)是一类穿膜的酪氨酸激酶受体 ,它们介导FGFs信号传递入细胞质中。目前已经确定了由 4种独立基因编码的FGFRs即FGFR1、FGFR2、FGFR3、FGFR4。FGFs/FGFRs在不同组织中 ,通过复杂的信号传递路径对细胞的增值、分化和移行进行调节。由于它们具有广泛的生物学功能 。
To date 21 members of fibroblast growth factor family have been identified. Among these, there are 9 members have been found in mammals. Fibroblast growth factor receptors are a group of transmembrane tyrosine-kinase receptors. They mediate transduction of FGF signals to the cytoplasm. Four human FGFR-encoding genes have been described. They are FGFR1, FGFR2, FGFR3, FGFR4. FGF/FGFR regulate cell proliferation, differentiation and migration in many different tissues through complex signaling pathways. Because of their multiple biological functions, they have great potential in clinical application.
出处
《药物生物技术》
CAS
CSCD
2004年第3期194-198,共5页
Pharmaceutical Biotechnology
