摘要
在慢性萎缩性胃炎(CAG)患者中随访观察幽门螺杆菌(HP)根除治疗前后血清学指标的变化。采用前瞻性研究方法,观察CAG患者在根除HP前后的血清胃蛋白酶原(PG)Ⅰ、PGⅡ、胃蛋白酶原Ⅰ/Ⅱ比值(PGR)、促胃液素-17(G-17)的变化,OLGA分期和OLGIM分期进行比较分析。CAG患者中,根除HP治疗结束6个月后来随访的患者共有36例,而在根除治疗12个月后来随访的患者共有51例。与根除治疗前比较,治疗6个月后的血清G-17水平下降,OLGA分期中Ⅲ期患者减少(P<0.05)。在成功根除HP 12个月后,CAG患者的血清PGR水平上升,而血清G-17水平下降;随访对象中萎缩患者减少;OLGA分期中的0期患者增加,OLGIM分期中的Ⅰ期患者也增加(P均<0.05)。根除HP可以部分逆转慢性胃炎中萎缩的发生,血清学指标可反映CAG严重程度的改变。
To observe the change of serum markers in chronic atrophic gastritis patients after Helicobacter pylori(HP)eradication by follow-up.The changes of serum pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),pepsinogen ratio(PGR)and gastrin-17(G-17),meanwhile pathological OLGA and OLGIM staging among chronic atrophic gastritis after eradication of HP through prospective study.Among the patients with chronic atrophic gastritis,36 cases were followed up 6 months after the eradication of HP,and 51 cases were followed up 12 months after the treatment.6 months after the eradication of HP,serum G-17 level in patients with chronic atrophic gastritis were lower than before eradication treatment,and patients of stageⅢreduced in OLGA staging.12 months after the eradication of HP,serum PGR level of patients with chronic atrophic gastritis was increased,while the serum G-17 level was decreased,and the positive rate of atrophy was decreased among the follow-up subjects.Meanwhile,patients of stage 0 increased in OLGA staging and stage I increased in OLGIM staging.Eradication of HP can partially reverse the occurrence of atrophy in chronic gastritis,and serum markers can reflect the change in the severity of chronic atrophic gastritis.
作者
刘德地
王亚雷
张磊
Liu Dedi;Wang Yalei;Zhang Lei(Dept of Gastroenterology,The First Affiliated Hospital of University of Science and Technology of China,Hefei 230031;Dept of Gastroenterology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022)
出处
《安徽医科大学学报》
CAS
北大核心
2019年第8期1329-1332,共4页
Acta Universitatis Medicinalis Anhui
基金
安徽省科技攻关计划项目(编号:1501ld04043)
