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慢性萎缩性胃炎黏膜中胃泌素、生长抑素与脾胃虚弱证的相关性研究 被引量:17

Correlative Study on the Type of Spleen-stomach Weakness and GAS, SS in Gastric Mucosa of Chronic Atrophy Gastritis
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摘要 目的测定黏膜中胃泌素(GAS)、生长抑素(SS)的水平,探讨慢性萎缩性胃炎(CAG)脾胃虚弱证与胃肠激素的相关性。方法选取患者74例,辨证为脾胃虚弱证者38例、脾胃湿热证者36例;另选取正常对照组35例,应用放射免疫分析法(RIA)测定胃黏膜中GAS、SS含量,进行不同中医证型间激素水平比较,并与正常对照组比较。结果CAG脾胃虚弱证、脾胃湿热证患者胃黏膜中GAS水平均显著高于正常对照组,在两中医证型间亦有差异,胃黏膜SS水平在两证型中均显著低于正常对照组。结论CAG患者胃黏膜中GAS水平显著高表达,SS水平显著低表达,可以部分反映脾胃虚弱证的本质,并可作为脾胃虚弱证的客观性诊断指标;脾胃虚弱和脾胃湿热患者胃黏膜中GAS水平的显著差异可以反映中医证型间的内在区别;黏膜中GAS、SS的异常表达,可能是CAG发生发展的部分内在因素。 Objective:To study the relationship between the gastrointestinal hormone and the spleen-stomach weakness type in chronic atrophy gastritis (CAG) through detecting the levels of GAS and SS.Methods:74 cases,containing 38 patients with Spleen-stomach weakness syndrome (SSAS) type and 36 patients with Spleen-stomach damp-heat syndrome (SSDH) type,were selected into the treatment group.35 health people were selected as the control group.After being detected levels by the RIA method,contents of GAS and SS were compared between two TCM syndrome groups.Meanwhile,these levels were compared between two groups.Results:The level of GAS with SSAS in gastric mucosa was significantly higher than that of the health people,but it was significantly lower than that of SSDH.In two TCM syndrome patients,the content of SS with SSAS in gastric mucosa is remarkably lower than that of the health people.Conclusion:In CAG patients,the GAS,which is high expression obviously,and the SS,which is low expression significantly,could be reflected the essence of the spleen-stomach weakness type.They could be the objective indicators of this TCM type.The significant difference of GAS between SSAS and SSDH indicates that distinction in these two TCM syndromes.Abnormal expressions of GAS and SS could be the internal factor partly in the CAG improvements.
出处 《中国中医急症》 2010年第5期786-787,799,共3页 Journal of Emergency in Traditional Chinese Medicine
关键词 慢性萎缩性胃炎 脾胃虚弱证 胃黏膜 胃泌素 生长抑素 Chronic atrophy gastritis Spleen-stomach weakness syndrome Gastric mucosa GAS SS
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