摘要
目的 探讨 p2 1、p5 3在肺癌中的临床意义及其相互关系。方法 采用流式细胞术检测 30例冻存的肺癌及 10例相应远离肿瘤部位的肺组织中 p2 1、p5 3的表达。 结果 肺癌组织中p2 1、p5 3的阳性率分别为 73 3%、76 7% ,各指标相对含量 (FI值 )明显高于远癌肺组织 (P <0 0 1) ,两者表达无显著性相关 (P =0 0 6 ) ,且均与肺癌分型、分期、分化程度等无关联。p5 3表达在吸烟患者 (94 1% )高于不吸烟患者 (5 3 8% ,P <0 0 5 )。p5 3阳性者术后 4～ 5年存活率较低 ,p2 1与 p5 3共阳性者术后生存期更短 (P <0 0 5 )。 结论 p5 3异常表达与肺癌术后生存相关 ,联合考虑p2 1时 ,仍然有预后意义。
Objective To investigate the clinical role of p21 and p53 in primary lung cancer and their relationship with each other. Methods p21 and p53 were measured in 30 frozen lung cancer and 10 corresponding noncancer tissues by flow cytometry(FCM). Results In lung cancer, the expression rates of p21 and p53 were 73 3%,76 7% respectively and these two proteins showed much higher FI values than in non cancer tissues( P <0 01). p21 and p53 alteration were independent of tumor size, metastasis, stage and histological type. As compared with the non smokers(53 8%), smokers showed strong expression of p53 (94 1%, P <0 05). 4～5 year survival rate of positives of p53 protein was lower than that of negative group. Coexpression of p21 and p53 related to a more shortened survival. Conclusion p53 alterations are associated with 4～5 year survival rate of patients underwent curative resection of lung neoplasms. Coexpression of p21 and p53 may suggest a more shortened survival of these patients.
出处
《安徽医科大学学报》
CAS
2003年第6期440-444,共5页
Acta Universitatis Medicinalis Anhui
