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肿瘤候选抑制基因RASSF1A 被引量：3

New candidate tumor suppressor gene RASSF1A
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摘要 新克隆的RASSF1A基因位于 3p2 1 3,是新的肿瘤候选抑制基因 ,能明显抑制肿瘤细胞生长。RASSF1A失表达见于多种实性肿瘤组织 ,与RASSF1A启动子甲基化密切相关。RASSF1A启动子甲基化检测可能是很有用的临床指标。
作者 邓征浩 周建华 文继舫
机构地区 中南大学湘雅医学院病理学教研室
出处 《国外医学（肿瘤学分册）》 2004年第11期806-809,共4页 Foreign Medical Sciences (Cancer Section)
关键词 ras蛋白质类 基因 NEF 基因 抑制 肿瘤 DNA甲基化
分类号 R730.23 [医药卫生—肿瘤]
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参考文献30

  • 1Lerman MI, Minna JD. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. Cancer Res, 2000,60(21): 6116-6133. 被引量：1
  • 2Burbee DG,Forgacs E,Zochbauer Muller S,et al. Epigenetic inactivation of RASSF1 A in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst,2001,93 (9) :691-699. 被引量：1
  • 3Dammann R, Li C, Yoon JH, et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3. Nat Genet,2000,25 (3) :315-319. 被引量：1
  • 4Agathanggelou A, Bieche I, Ahmed Choudhury J, et al. Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1 A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma. Cancer Res,2003,63 (17) :5344-5351. 被引量：1
  • 5Vos MD, Ellis CA, Bell A, et al. Ras use the novel tumor suppressor RASSF1 as an effector to mediate apoptosis. J Biol Chem,2000,275(46): 35669-35672. 被引量：1
  • 6Ortiz Vega S, Khokhlatchev A,Nedwidek M,et al. The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. Oncogene ,2002,21 (9): 1381-1390. 被引量：1
  • 7Liu L, Tommasi S, Lee DH, et al. Control of microtubule stability by the RASSF1A tumor suppressor. Oncogene, 2003,22(50): 8125-8136. 被引量：1
  • 8Song MS,Song SJ,Ayad NG,et al. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol,2004,6 (2): 129-137. 被引量：1
  • 9Dreijerink K, Braga E, Kuzmin I, et al. The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis. Proc Natl Acad Sci USA ,2001,98 (13) :7504-7509. 被引量：1
  • 10Shivakumar L, Minna J, Sakamaki T, et al. The RASSF1 A tumor suppressor blocks cell cycle progression and inhibits cyclinD1 accumulation. Mol Cell Biol,2002,22(12) :4309-4318. 被引量：1

同被引文献28

  • 1Kok K, Naylor SL, Buys CH, et al. Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes[J]. Adv cancer Res,1997,71(1):27-92. 被引量：1
  • 2Dammann R, Li C, Yoon JH, et al. Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3[J]. Nat Genet, 2000,25(3): 315-319. 被引量：1
  • 3Michael IL, Minna JD. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes[J]. Cancer Res,2000, 60(21):6116-6133. 被引量：1
  • 4Whang-peng J, Kao-Shan CS, Lee EC, et al. Specific chromosome defect associated with human small-cell lung cancer; deletion 3p(14-23)[J]. Science,215 (4529):181-182. 被引量：1
  • 5Agathanggelou A, Bieche I, Ahmed-Choudhury J, et al. Identification of novel gene expression targets for the Ras association domain family 1 (RASSF1A) tumor suppressor gene in non-small cell lung cancer and neuroblastoma[J]. Cancer Res, 2003, 63 (17):5344-5351. 被引量：1
  • 6Shivakumar L, Minna J, Sakamaki T, et al. The RASSF1A tumor suppressor blocks cell cycle progression and inhibits cyclinD1 accumulation[J]. Mol Cell Biol, 2002, 22(12):4309-4318. 被引量：1
  • 7Burbee DG, Forgacs E, Zochbauer-Muller S, et al. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression[J]. J Natl Cancer Inst, 2001,93(9): 691-699. 被引量：1
  • 8Dreijerink K, Braga E, Kuzmin I, et al.The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis[J]. Proc Natl Acad Sci USA, 2001,98(13): 7504-7509. 被引量：1
  • 9Michele DV, Chad AE, Aaron B, et al. Ras use the novel tumor suppressor RASSF1 as an effector to mediate apoptosis[J]. J Biol Chem,2000,275(46):35669-35672. 被引量：1
  • 10Burbee DG, Forgacs E, Zcchbauer MS, et al. Epigenetic inactivation of RASSFIA in lung and breast cancers and malignant phenotype suppression. J Natl Cancer Inst,2001,93:691-699. 被引量：1

引证文献3

二级引证文献6

国外医学（肿瘤学分册）
2004年 第11期

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