摘要
目的研究nm23、p53和bc1-2蛋白的表达与鼻咽癌(NPC)生物学行为及预后的关系。方法 应用免疫组织化学SP法检测64例NPC组织中nm23、p53和bc1-2蛋白的表达。结果 64例NPC中nm23、p53和bc1-2蛋白的阳性表达率分别为54.7％(35/64)、29.7％(19/64)、81.3％(52/64),nm23、p53和bc1-2蛋白表达均与NPC的淋巴结转移和预后有关(P<0.05～0.005),与TNM分期无关(P>0.05)。结论nm23、p53和bc1-2蛋白的表达参与了NPC的发生、发展并影响其预后。
Objective To study the relationship between the expression of nm23, p53, bcl-2 and prognosis in nasopharyngeal carcinoma(NPC). Methods The expression of nm23, p53, bcl-2 protein in 64 cases NPC were studied by immunohistochemistry of SP. Results The positively rates of nm23, p53,bcl-2 were related to the lymph node metastasis and prognosis in NPC(P<0. 005~0. 05). Conclusion The nm23, p53,bcl-2 were involved in the tumorigenesis, development and prognosis in NPC.
出处
《贵州医药》
CAS
2004年第1期22-23,共2页
Guizhou Medical Journal
基金
贵州省科委基金资助项目(E97-3)
