摘要
目的 探讨消化系统神经内分泌癌的临床病理特点及其组织发生和预后。方法 回顾性分析2 1例消化系统神经内分泌癌的临床病理资料 ,对肿瘤进行光镜观察 ,并做免疫组化。结果 消化系统神经内分泌癌可分为三个临床病理类型 ,其病理学特点、生物学行为及预后均有不同。本组资料中典型类癌 6例 ,不典型类癌 7例 ,小细胞癌 8例。免疫组织化学上 ,NSE阳性 14例 ,Syn阳性 14例 ,CgA阳性 4例。随访期内三种类型生存率分别为 6 6 .7%、5 0 %、5 7.1%。结论 消化系统神经内分泌癌病理类型及临床分期与预后密切相关 ,对其治疗有指导作用 ,免疫组化的合理应用可提高神经内分泌癌的诊断率 ,组织发生上支持来自全能干细胞。
Objective To study the clinical pathological character,histogenesis and prognosis of neuroendocrine tumors in digestive system. Methods The clinical pathological data of 21patients were analyzed retrospectively,some of them immunochemically stained with NSE,Syn,CgA,CK and EMA,all of them observed under microscope. Results The 21 neuroendocrine tumors of digestive system were divided into three types: Type Ⅰ,typical carcinoid ,altogether 6 cases, three of them belong to advanced type. Type Ⅱ,atypical carcinoid,totally 7 cases, they all were advanced type. Type Ⅲ,small cell carcinoma, altogether 8 cases, five of them were advanced type. These three neuroendocrine tumors showed different histological morphological character and biological behavior. Immunohistochemically, 14,14,4 cases showed positive immunoreactions to NSE, Syn, CgA respectively. Conclusion The clinico-pathological classification and staging of neuroendocrine tumors in digestive system are related to prognosis closely. A correct identification is important and implicit for the treatment. The application of immunohistochemical method may raise the diagnostic rate of neuroendocrine tumors. This kind of tumor may origin from the multipotent stem cells.
出处
《肿瘤防治研究》
CAS
CSCD
2004年第1期51-53,共3页
Cancer Research on Prevention and Treatment
