摘要
本实验利用家兔机械性小肠梗阻模型探讨了动脉、门脉血及肠壁组织的胃肠激素水平与病理改变及十二指肠运动的关系。完全性小肠梗阻后,血中血管活性肠肽(VIP)、P物质(SP)及十二指肠壁VIP含量较对照组升高,血中胃泌素(Gas)降低,结肠组织VIP、SP较对照组减低(P均<0.05)。门脉血激素水平高于动脉血且呈正相关,腹水中可检出上述激素免疫活性。结果提示胃肠激素是影响肠梗阻病变的重要活性物质。
In order to investigate what substance mediates the pathophysiologic alterations accom-panying small bowel obstruction, we determined vasoactive intestinal polypeptide(VIP), Substance P (SP), Somatostatin (SS) and Gastrin (Gas) in rabbit acute me-chanical small bowel obstruction model. The levels of arterial and portal blood and theconcentration of bowel tissue were measured. It was found that plasma VIP, SP levels were significantly elevated 24 hours afterligating the ileum, but Gas was lowered (P<0.05). Duodenal VIP concentration wasincreased with lowel obstruction, as compared with controls. While colonic VIP andSP values were decreased (P<0.05). A positive correlation was noted between arterialand portal gut hormone levels. Immunoactivity of VIP, SP, SS, Gas in peritoneal fluidwas detected. It was demonstrated that gut hormones played an important role in smallbowel obstruction.
出处
《天津医药》
CAS
1992年第11期654-657,共4页
Tianjin Medical Journal
基金
国家自然科学基金
关键词
肠梗阻
病理
胃肠道激素
bowel obstruction
vasoactive intestinal polypeptide substance P
somatostatin gastrin
