摘要
目的 观察血管紧张素Ⅱ受体拮抗剂替米沙坦治疗左心心力衰竭的临床疗效。方法 观察门诊及住院的左心功能不全病人 5 8例 ,其中男性 35例 ,女性 2 3例 ,平均年龄 (6 3± 7)岁 ;心功能在NYHAⅡ～Ⅳ。将其随机分为替米沙坦治疗组和雷米普利对照组 ,在常规强心、利尿、扩血管等治疗基础上 ,替米沙坦治疗组加用替米沙坦 80mg/次口服 ,每日 1次。雷米普利对照组加用雷米普利 5mg/次口服 ,每日 1次。结果 在治疗 6个月期间 ,与治疗前相比两组病人心功能得到明显改善 ,P <0 0 1。治疗组总有效率为89 6 5 % ,对照组为 92 85 %。 χ2 =0 5 8,P >0 0 5。治疗组心功能改善与对照组无显著性差别。使用替米沙坦后 3个月及 6个月左室舒张末内径、左室射血分数指标均显著改善(P <0 0 1)。结论 替米沙坦用于抗心衰治疗与血管紧张素转换酶抑制剂同样有效 ,特别是当应用ACEI出现咳嗽等副作用时 ,可作为理想的替代药物 .
Objectives To observe the efficacy of angiotensin-Ⅱ receptor antagonist (Telmisartan) for treatment of chronic left heart failure. Methods 58 patients (35 males; mean age 63 years) with chro-nic left heart failure were randomly divided into two groups, both of them were treated on basic heart failure therapy, such as digitalis, diuretics etc. One group received treatment of an 80 mg/day of Telmisartan, and the other received angiotensin converting enzyme inhibitor (Ramipil, 5 mg/day). The follow-up was 6 months. Results The symptoms wife significantly improved in both groups comparing with that before therapy (P<0.01). There was no significant difference in the total effective rate between two groups (89.65% vs 92.85%, P>0.05). The left ventricular end-diastolic diameters were reduced and LVEFs were significantly improved in Telmisartan group after 3 months and 6 months treatment. Conclusions Telmisartan is as effective as ACEI on treatment of left heart failure. It can substitute for the ACEI if its adverse effect happened.
出处
《岭南心血管病杂志》
2003年第6期420-422,共3页
South China Journal of Cardiovascular Diseases
