摘要
目的研究替米沙坦对动脉粥样硬化的作用及高血压的疗效。方法45例高血压伴缺血性脑血管病(治疗组)患者使用替米沙坦40mg,po,qd×31w;43例高血压伴缺血性脑血管病(对照组)患者使用非洛地平5mg,po,qd×31w治疗。采用颈动脉超声检查,观察动脉粥样硬化程度。结果治疗组颈动脉中膜增厚、斑块或血栓及颈动脉狭窄发生与对照组比较有显著性差异(P<0.01),治疗组应用替米沙坦1w后显著降压(P<0.05),31w持续平稳降压(P<0.01),降压总有效率1w为57%,31w达93%。结论替米沙坦有效调控血压抑制内皮功能异常和内膜增生反应,可保护血管内皮和改善血管重构,抑制动脉粥样硬化。
Objective To observe the efficacy of telmisartan on restraining atherosclerosis and its way to control hypertension. Methods The patients with EH （n=45） were treated with telmisartan 40mg, po, qd, for 31w. The patients with EH （n=43） were treated with Felodipine 5mg, po, qd, for 31w. Use color duplex sonography for evaluating extracoranial. Results The intima-media thickness, the delection rate of atherosclerosis plaque, and the incidence of carotid artery stenosis in CI group were significantly different from controls （P 〈0.01） .At the end of 1w, BP decreased significandy in patients with EH treated with telmisartan （P〈 0.01）, BP decreased continuously up to 31w. The total hypotensive rate of valsartan was 57% at lw and 93% at 31w repectively. Conclusion Telmisartan has significant control on hypertension, restraining vascular endothelial function unusually and the reflection of membrane hyperplasia, protects vascular endothelium, improves reconstruction of vascular and restrains atherosclerosis.
出处
《中国现代医生》
2007年第08X期30-31,44,共3页
China Modern Doctor
