摘要
目的观察美托洛尔联合曲美他嗪对老年冠心病合并心力衰竭患者血清炎性因子水平和免疫功能的影响。方法将94例老年冠心病合并心力衰竭患者按随机数表法分为A组和B组,各47例。A组患者在常规治疗的基础上接受美托洛尔治疗,B组患者在A组治疗的基础上加服曲美他嗪。统计两组患者治疗总有效率,对比两组患者治疗前后CRP、CD4^+、CD8^+水平。结果 B组患者治疗总有效率(95. 74%)高于A组(80. 85%),差异有统计学意义(P <0. 05);治疗后两组患者CRP水平均有明显下降(P <0. 05),B组患者治疗后CRP水平低于A组(P <0. 05);治疗后B组患者CD4^+水平高于A组(P <0. 05)。结论美托洛尔联合曲美他嗪治疗老年冠心病合并心力衰竭临床效果较好,能有效减轻炎症反应,改善免疫功能,具有临床推广价值。
Objective To observe the effect of metoprolol combined with trimetazidine on the serum levels of inflammatory factor and immune function in elderly patients with coronary artery heart disease combined with heart failure. Methods Ninety-four elderly patients with coronary heart disease and heart failure were randomly divided into group A and group B,47 cases in each group. Group A received metoprolol on the basis of routine treatment,while group B received trimetazidine on the basis of group A. The total effective rate of the two groups was counted,and the levels of CRP,CD4^+,CD8^+ before and after treatment were compared between the two groups. Results The total effective rate of group B( 95. 74%) was higher than that of group A( 80. 85%),and the difference was statistically significant( P < 0. 05). After treatment,the CRP level of both groups decreased significantly( P < 0. 05),while that of group B was lower than that of group A( P < 0. 05).After treatment, the CD4^+ level of group B was higher than that of group A( P < 0. 05).Conclusion Metoprolol combined with trimetazidine in the treatment of elderly patients with coronary heart disease complicated with heart failure has a good clinical effect,can effectively reduce inflammation,improve immune function,and has clinical popularization value.
作者
卢博
胡建华
Lu Bo;Hu Jianhua(Department of Cardivascular Medicine,Xi’an Central Hospital,Xi’an 710000,China)
出处
《中华心脏与心律电子杂志》
2018年第3期161-163,共3页
Chinese Journal of Heart and Heart Rhythm(Electronic Edition)
关键词
冠心病
心力衰竭
美托洛尔
曲美他嗪
Coronary heart disease
Heart failure
Metoprolol
Trimetazidine
