摘要
目的探讨中老年支气管哮喘急性发作期中医证型特征及其与呼出气一氧化氮(FeNO)的相关性。方法选择2017年10月-2018年8月中国中医科学院望京医院呼吸科门诊40岁以上中老年支气管哮喘急性发作期患者,进行中医辨证,测定其肺功能、FeNO,进行统计分析。结果共纳入患者179例,其中冷哮证24例、热哮证43例、寒包热哮证16例、风痰哮证56例、虚哮证40例。不同证型患者病程比较差异有统计学意义(P<0.05)。虚哮证患者年龄高于其他患者(P<0.05)。虚哮证患者第1秒用力呼气容积占预计值百分比低于热哮证、寒包热哮证患者,差异有统计学意义(P<0.05)。风痰哮证患者Fe NO高于热哮证、虚哮证患者,差异有统计学意义(P<0.05)。轻度气道炎症者证型分布为热哮证(35%)>虚哮证(33%)>风痰哮证(15%)>冷哮证(12%)>寒包热哮证(5%),重度炎症者证型分布为风痰哮证(44%)>热哮证(18%)>虚哮证(15%)>冷哮证(14%)>寒包热哮证(10%),不同气道炎症程度患者的中医证型分布差异有统计学意义(P<0.05)。结论中老年支气管哮喘急性发作期以风痰哮证、热哮证、虚哮证为主,虚哮证患者病程最长且高龄患者多见,风痰哮证在重度炎症患者中的分布和FeNO水平均高于其他患者,FeNO可能为中老年支气管哮喘急性发作期中医证型的客观化提供依据。
Objective To investigate the characteristics of TCM syndromes in middle-aged and elderly patients with acute attack of bronchial asthma and their correlation with fractional exhaled nitric oxide(FeNO).Methods According to the symptoms,signs,tongue and pulse of patients with acute bronchial asthma in the patients over 40 years old who were admitted to the respiratory outpatient of Wangjing Hospital of China Academy of Chinese Medical Sciences from October 2017 to August 2018,TCM syndrome differentiation was carried out.FeNO and lung function were detected for statistical analysis.Results Totally 179 patients were collected,including 24 cases of cold asthma,43 cases of heat asthma,16 cases of cold with heat asthma,56 cases of wind-phlegm asthma,and 40 cases of deficiency asthma.The difference of disease course among the patients with different syndrome types was statically significant(P<0.05).The age of deficiency asthma patients was older than other types of asthma(P<0.05).Forced expiratory volume in the first second as a percentage of predicted value of deficiency asthma patients was lower than the heat asthma and cold with heat asthma,with statistical significance(P<0.05).FeNO of wind-phlegm asthma patients was higher than the patients with heat asthma and deficiency asthma,with statistical significance(P<0.05).Airway inflammation in patients with different syndromes showed that,mild inflammation:heat asthma(35%)>deficiency asthma(33%)>wind-phlegm asthma(15%)>cold asthma(12%)>cold with heat asthma(5%);severe inflammation:wind-phlegm asthma(44%)>heat asthma(18%)>deficiency asthma(15%)>cold asthma(14%)>cold with heat asthma(10%),and the distribution of syndrome types among patients with different degree of airway inflammation was statically significant(P<0.05).Conclusion The acute attack of bronchial asthma is dominated by wind-phlegm asthma,cold asthma and deficiency asthma.Deficiency asthma syndrome has the longest course of disease and is mostly seen in elderly patients.The distribution of severe inflammation a
作者
朱秀影
谢惠芳
韩海
高峰
ZHU Xiuying;XIE Huifang;HAN Hai;GAO Feng(Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China;Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《中国中医药信息杂志》
CAS
CSCD
2019年第7期12-15,共4页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
支气管哮喘急性发作期
中医证型
呼出气一氧化氮
肺功能
acute attack of bronchial asthma
TCM syndromes
fractional exhaled nitric oxide
pulmonary function
