摘要
目的探讨氨氯地平联合瑞舒伐他汀对高血压合并高血脂患者疗效。方法选取自2017年1月至2018年1月武警湖北总队医院收治的高血压合并高血脂患者643例作为研究对象。按照用药不同分为A、B两组,A组,硝苯地平联合瑞舒伐他汀;B组,氨氯地平联合瑞舒伐他汀。观察两组患者6个月的治疗效果;两组患者治疗前后血压、血脂、心、肝和肾功能情况;两组患者治疗前和治疗后6个月并发症发生率比较。结果治疗后6个月,A组患者总有效率为82.0%(297/362)低于B组95.7%(269/281);两组患者治疗后血压、血脂和心功能得到改善,但肝功能和肾功能受损;但B组血压、血脂和心功能改善优于A组,肝功能和肾功能受损低于A组,差异具有统计学意义(P<0.05)。治疗后6个月,A组患者内并发症发生率36.2%(131/362)高于B组24.2%(68/281),差异具有统计学意义(P<0.05)。结论氨氯地平联合瑞舒伐他汀具有更佳的降压、降脂效果,具有更小的心、肝和肾毒性,更低的不良事件发生率,值得推广。
Objective To investigate the effect of amlodipine combined with rosuvastatin on patients with hypertension and hyperlipidemia.Method 643 patients with hypertension and hyperlipidemia admitted to Hubei General Team Hospital of Armed Police Force from January 2017 to January 2018 were selected as the study subjects.The patients were divided into group A,nifedipine combined with rosuvastatin,and group B,amlodipine combined with rosuvastatin.The treatment effect of the two groups was observed for 6 months.The blood pressure,blood lipid,heart,liver and kidney function of the two groups before and after treatment were observed.The incidence of complications was compared between the two groups before and after treatment for 6 months.Result Six months after treatment,the total effective rate of group A was 82.0%(297/362)lower than that of group B 95.7%(269/281).After treatment,blood pressure,blood lipid and cardiac function were improved,but liver function and renal function were impaired.However,the improvement of blood pressure,blood lipid and cardiac function in group B was better than that in group A,and the impairment of liver function and renal function was lower than that in group A(P<0.05).Six months after treatment,the incidence of complications in group A was 36.2%(131/362)higher than that in group B(24.2%(68/281),the difference was statistically significant(P<0.05).Conclusion Amlodipine combined with rosuvastatin has better antihypertensive and lipid-lowering effects,less cardiotoxicity,liver and kidney toxicity,and lower incidence of adverse events,which is worthy of promotion.
作者
曹阳
张平
Cao Yang;Zhang Ping(Department of Outpatient,Wuhan Fourth Military Division,Hubei Military Region,Hubei 430015,China;Department of Internal Medicine,Chinese People's Armed Police Force Hubei Provincial General Hospital,Hubei 430070,China)
出处
《血管与腔内血管外科杂志》
2019年第2期156-160,共5页
Journal of Vascular and Endovascular Surgery
